Nichtinvasive Analyse des Knorpelvolumens und der Knorpeldicke im menschlichen Ellbogengelenk mittels MRT

Springer, Verena; Grakhen, H.; Stammberger, Tobias; Englmeier, Karl‐Hans; Reiser, Maximilian; Eckstein, F.

doi:10.1016/s0940-9602(98)80038-1

Cited by 9 publications

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, a higher association was found with the local bone size (diameter of the tibial head and the humeral condyles, respectively; Eckstein et al 1998c;Springer et al 1998). In a sample of men (Eckstein et al 2001a), the correlations between cartilage volume and body weight/height were also found to be low (r=0.06 to 0.27/0.28 to 0.45 for the various cartilage plates, whereas the size of the bones was shown to display higher correlation coefficients with the cartilage volume (r=0.39 to 0.67).…”

Section: Scale Effects and Correlation With Anthropometric Variablesmentioning

confidence: 93%

“…A subsequent study in 27 adult men (Eckstein et al 2001a) confirmed that a high degree of variability is also present within one gender (CV% ~20%), and that the variability of cartilage volume is determined both by considerable variation in cartilage thickness and joint surface areas (CV% ~15%, respectively). A high interindividual variability has also been described in the elbow (Springer et al 1998) and in the joints of the hind foot (Al-Ali et al 2001).…”

Section: Inter-individual Variability and Side Differencesmentioning

confidence: 96%

See 1 more Smart Citation

In vivo morphometry and functional analysis of human articular cartilage with quantitative magnetic resonance imaging - from image to data, from data to theory

Eckstein¹,

Reiser

Englmeier

et al. 2001

Anatomy and Embryology

Self Cite

160

126

View full text Add to dashboard Cite

Analyses of form-function relationships and disease processes in human articular cartilage necessitate in vivo assessment of cartilage morphology and deformational behavior. MR imaging and advanced digital post-processing techniques have opened novel possibilities for quantitative analysis of cartilage morphology, structure, and function in health and disease. This article reviews work on three-dimensional post-processing of MR image data of articular cartilage, summarizing studies on the accuracy and precision of quantitative analyses in human joints. It presents normative values on cartilage volume, thickness, and joint surface areas in the human knee, and describes the correlation between different joints and joint surfaces as well as their association with gender, body dimensions, and age. The article summarizes ongoing work on functional adaptation of articular cartilage to mechanical loading, analyses of in situ cartilage deformation in intact joints in vivo and in vitro, and the quantitative evaluation of cartilage tissue loss in osteoarthritis. We describe evolving techniques for assessment of the structural/biochemical composition of articular cartilage, and discuss future perspectives of quantitative cartilage imaging in the context of joint mechanics, mechano-adaptation, epidemiology, and osteoarthritis research. Specifically, we show that fat-suppressed gradient echo sequences permit valid analysis of cartilage morphology, both in healthy and severely osteoarthritic joints, as well as highly reproducible measurements (CV%=1 to 3% in the knee, and 2 to 10% in the ankle). Relatively small differences in cartilage morphology exist between both limbs of the same person (approximately 5%), but large differences between individuals (CV% approximately 20%). Men display only slightly thicker cartilage then women (approximately 10%), but significantly larger joint surface areas (approximately 25%), even when accounting for differences in body weight and height. Weight and height represent relatively poor predictors of cartilage thickness (r2 <15%), but muscle cross section areas display more promising correlations (r2 >40%). The level of physical exercise (sportive activity) does not account for interindividual differences in cartilage thickness. The thickness appears to decrease slightly in the elderly--in particular in women, even in the absence of osteoarthritic cartilage lesions. Strenuous physical exercises (e.g., knee bends) cause a 6% patellar cartilage deformation in young individuals, but significantly less deformation in elderly men and women (<3%). The time required for full recovery after exercise (fluid flow back into the matrix) is relatively long (approximately 90 min). Static in situ compression of femoropatellar cartilage with 150% body weight produces large deformations after 4 h (approximately 30% volume change), but only very little deformation during the first minutes of loading. Quantitative analyses of magnetization transfer and proton density hold promise for biochemical evaluation of a...

show abstract

Section: Scale Effects and Correlation With Anthropometric Variablesmentioning

confidence: 93%

Section: Inter-individual Variability and Side Differencesmentioning

confidence: 96%