PLoS ONE volume 9, issue 5, Pe98313 2014 DOI: 10.1371/journal.pone.0098313 View full text
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Aline Couturier, Janine Keller, Erika Most, Robert Ringseis, Klaus Eder

Abstract: Administration of pharmacological niacin doses was recently reported to have pronounced effects on skeletal muscle gene expression and phenotype in obese Zucker rats, with the molecular mechanisms underlying the alteration of gene expression being completely unknown. Since miRNAs have been shown to play a critical role for gene expression through inducing miRNA-mRNA interactions which results in the degradation of specific mRNAs or the repression of protein translation, we herein aimed to investigate the influ…

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