Niacin: Antipellagra Factor, Hypocholesterolemic Agent

Goldsmith, Grace A.

doi:10.1001/jama.1965.03090150059014

Cited by 14 publications

(3 citation statements)

References 29 publications

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“…The conversion of trp to niacin occurs at maximum rate when trp requirements are covered (Olcese et al, 1949), a condition fulfilled with our experimental pellet. Although this conversion is inefficient (67:1, Olcese et al, 1949;Goldsmith, 1965), it could supply enough niacin when trp rich food is available ad libitum, as it was the case in our experiment. However, as maize tissues are not only deficient in niacin but also in trp, this pathway may be limited in the wild.…”

Section: Discussionmentioning

confidence: 69%

The effect of dietary niacin deficiency on reproduction of European brown hares: An experimental study

Selimovic

Tissier²,

Stalder³

et al. 2023

Front. Ecol. Evol.

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Large plots of maize in agricultural landscapes are associated with reduced reproductive output of females and impaired population development of free-living populations of European brown hares (Lepus europaeus, Pallas 1778). We investigated in captive brown hares experimentally whether these effects could result from an undersupply of niacin due to a suspected maize-biased diet in such areas. We repeatedly mated adult female hares, fed ad libitum either with a niacin deficient pellet mainly consisting of maize plant parts, or with the same pellet enriched with niacin to meet physiological requirements. We measured effects of the experimental feeding on body mass of females, reproductive output, growth and survival of leverets. We found significantly higher body mass of females fed the control pellet, and faster body mass gain of their leverets until standardized weaning. We found no significant difference between niacin deficient and control diet groups in reproductive output of females and survival rates of leverets. Our results show that even a diet severely depauperate of niacin affects reproductive success of female brown hares only slightly, presumably because of sufficient conversion of tryptophan to niacin, or of additional supply of niacin by caecal microorganism.

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Section: Discussionmentioning

confidence: 69%

The effect of dietary niacin deficiency on reproduction of European brown hares: An experimental study

Selimovic

Tissier²,

Stalder³

et al. 2023

Front. Ecol. Evol.

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“…Methysergide, a drug used in the treatment of migraine, has been reported to product a thickened, reddened 'orange-peel' skin in some patients (Graham, 1964). Nicotinic acid, when administered in large doses, may cause brown pigmentation (Goldsmith, 1965). A blue-black pigmentation appeared on the exposed areas of the face and arms of a man treated with high doses of hydrochlorothiazide for 14 months (Sanatove, 1965).…”

Section: Other Drugsmentioning

confidence: 99%

Drug induced changes in pigmentation

Levantine

Almeyda²

1973

Br J Dermatol

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“…It has for example been used in matrices for matrixassisted laser desorption ionization (MALDI) mass spectrometry analyses of large polypeptides [1], as a reference material for combustion calorimetry [2,3], and particularly as an active pharmaceutical ingredient (API) in the treatment of hypercholesterolemia and atherosclerosis [4,5]. It has also long been recognized as a watersoluble vitamin (vitamin B 3 or niacin) [6,7] indispensable in the diet of humans and animals and, as such, widely used as additive in food, forage, and cosmetics [8,9]. Some recent estimates of the world demand for compounds of the nicotinic acid family point to 35,000 t to 40,000 t [10][11][12].…”

Section: Introductionmentioning

confidence: 99%