NHG-Standaard Kinderen met koorts

Berger, M Y; Boomsma, LJ; Albeda, F W; Dijkstra, R H; Graafmans, T A; Laan, JR Van der; Lemmen, W H; Oteman, N

doi:10.1007/978-90-313-8279-8_1

Cited by 3 publications

(3 citation statements)

References 86 publications

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“…For GePaRD values reach prevalence rates greater than 480 (48% of children in one year) for 3-year-olds. In Germany, United Kingdom and Italy, ibuprofen is the drug of choice beside paracetamol (acetaminophen) for fever in children [ 21 - 23 ], whereas in the Netherlands paracetamol is considered first [ 24 ]. In THIN and Pedianet prevalence rates were also higher in children below the age of 4, whereas for other databases prevalence rates were steadily increasing with age and peak at the age of 18.…”

Section: Discussionmentioning

confidence: 99%

Population-based analysis of non-steroidal anti-inflammatory drug use among children in four European countries in the SOS project: what size of data platforms and which study designs do we need to assess safety issues?

et al. 2013

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BackgroundData on utilization patterns and safety of non-steroidal anti-inflammatory drugs (NSAIDs) in children are scarce. The purpose of this study was to investigate the utilization of NSAIDs among children in four European countries as part of the Safety Of non-Steroidal anti-inflammatory drugs (SOS) project.MethodsWe used longitudinal patient data from seven databases (GePaRD, IPCI, OSSIFF, Pedianet, PHARMO, SISR, and THIN) to calculate prevalence rates of NSAID use among children (0–18 years of age) from Germany, Italy, Netherlands, and United Kingdom. All databases contained a representative population sample and recorded demographics, diagnoses, and drug prescriptions. Prevalence rates of NSAID use were stratified by age, sex, and calendar time. The person-time of NSAID exposure was calculated by using the duration of the prescription supply. We calculated incidence rates for serious adverse events of interest. For these adverse events of interest, sample size calculations were conducted (alpha = 0.05; 1-beta = 0.8) to determine the amount of NSAID exposure time that would be required for safety studies in children.ResultsThe source population comprised 7.7 million children with a total of 29.6 million person-years of observation. Of those, 1.3 million children were exposed to at least one of 45 NSAIDs during observation time. Overall prevalence rates of NSAID use in children differed across countries, ranging from 4.4 (Italy) to 197 (Germany) per 1000 person-years in 2007. For Germany, United Kingdom, and Italian pediatricians, we observed high rates of NSAID use among children aged one to four years. For all four countries, NSAID use increased with older age categories for children older than 11. In this analysis, only for ibuprofen (the most frequently used NSAID), enough exposure was available to detect a weak association (relative risk of 2) between exposure and asthma exacerbation (the most common serious adverse event of interest).ConclusionsPatterns of NSAID use in children were heterogeneous across four European countries. The SOS project platform captures data on more than 1.3 million children who were exposed to NSAIDs. Even larger data platforms and the use of advanced versions of case-only study designs may be needed to conclusively assess the safety of these drugs in children.

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Section: Discussionmentioning

confidence: 99%

Population-based analysis of non-steroidal anti-inflammatory drug use among children in four European countries in the SOS project: what size of data platforms and which study designs do we need to assess safety issues?

et al. 2013

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“…In some studies, the duration of fever prior to presentation has been shown to be a predictor of serious bacterial infection (SBI) [ 2 - 6 ]. However, the evidence for this association remains a subject of discussion [ 7 ]. For example, in the practice guideline for the management of febrile children in primary care, the Dutch College of General Practitioners (NHG) recommends that children with more than three days of fever at presentation should be seen by a general practitioner (GP) [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, the evidence for this association remains a subject of discussion [ 7 ]. For example, in the practice guideline for the management of febrile children in primary care, the Dutch College of General Practitioners (NHG) recommends that children with more than three days of fever at presentation should be seen by a general practitioner (GP) [ 7 ]. In contrast, the NICE guideline for feverish illness in children in the UK states that duration of fever should not be used to predict the likelihood of serious illness, other than Kawasaki disease [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Duration of fever and serious bacterial infections in children: a systematic review

et al. 2011

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BackgroundParents of febrile children frequently contact primary care. Longer duration of fever has been related to increased risk for serious bacterial infections (SBI). However, the evidence for this association remains controversial. We assessed the predictive value of duration of fever for SBI.MethodsStudies from MEDLINE, Embase and Cochrane databases (from January 1991 to December 2009) were retrieved. We included studies describing children aged 2 months to 6 years in countries with high Haemophilus influenzae type b vaccination coverage. Duration of fever had to be studied as a predictor for serious bacterial infections.ResultsSeven studies assessed the association between duration of fever and serious bacterial infections; three of these found a relationship.ConclusionThe predictive value of duration of fever for identifying serious bacterial infections in children remains inconclusive. None of these seven studies was performed in primary care. Studies evaluating the duration of fever and its predictive value in children in primary care are required.

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Randomised controlled trial

Jong

Dijk

2013

HUISARTS WETENSCHAP

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NHG-Standaard Kinderen met koorts

Cited by 3 publications

References 86 publications

Population-based analysis of non-steroidal anti-inflammatory drug use among children in four European countries in the SOS project: what size of data platforms and which study designs do we need to assess safety issues?

Population-based analysis of non-steroidal anti-inflammatory drug use among children in four European countries in the SOS project: what size of data platforms and which study designs do we need to assess safety issues?

Duration of fever and serious bacterial infections in children: a systematic review

Randomised controlled trial

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