2011
DOI: 10.1016/j.yexcr.2011.05.026
|View full text |Cite
|
Sign up to set email alerts
|

NHE1 mediates MDA-MB-231 cells invasion through the regulation of MT1-MMP

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

4
44
0

Year Published

2011
2011
2022
2022

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 52 publications
(50 citation statements)
references
References 36 publications
4
44
0
Order By: Relevance
“…Interestingly, we have shown in this study that NHE7-overexpression facilitates tumor invasion, cell-overlay and tumor formation in vivo. NHE1 is known to facilitate tumor invasion by acidifying the local pH and thereby activating pH-sensitive enzymes that degrade the extracellular matrix (9, [40][41][42][43][44][45]. In agreement, we also showed that overexpression of NHE1 in MDA-MB-231 cells enhances cell invasion (N1 in Fig.…”
Section: Discussionsupporting
confidence: 82%
“…Interestingly, we have shown in this study that NHE7-overexpression facilitates tumor invasion, cell-overlay and tumor formation in vivo. NHE1 is known to facilitate tumor invasion by acidifying the local pH and thereby activating pH-sensitive enzymes that degrade the extracellular matrix (9, [40][41][42][43][44][45]. In agreement, we also showed that overexpression of NHE1 in MDA-MB-231 cells enhances cell invasion (N1 in Fig.…”
Section: Discussionsupporting
confidence: 82%
“…In breast cancer cells, NHE1 activity increases expression of MMP2 stimulator membrane type 1 MMP via ERK1/2 and p38 mitogen-activated protein kinase signaling pathways (46). NHE1 and ERK1/2 signaling activations are also involved in fibronectin-induced enhancement of MMP2 and F-actin expression and cell migration (31).…”
Section: Nhe1 In Gbmmentioning
confidence: 99%
“…Acidic extracellular pH increases MMP-9 expression, and pharmacological inhibition of NHE-1 downregulates MT1-MMP, a key activator of MMP-2. 105,106 Intracellular trafficking via lyosomes and vesicles targets these proteases to invadopodia, a process that is dependent upon tumor microenvironmental pH. 107,108 In prostate cancer cells, NHE-1 activity promotes lysosomal fusion to invadopodia; these lysosomes then release cathepsin B to facilitate ECM proteolysis.…”
Section: Growth Factorsmentioning
confidence: 99%