Chiral indoles annulated
on the benzene ring are unique and significant
in natural and medicinal compounds. However, accessing these enantioenriched
molecules has often been overlooked. The present study introduces
an organocatalytic protocol to access these compounds efficiently,
demonstrated by substrate scope, functional group tolerance, and using
only 1 mol % of a chiral conjugated acid catalyst. Additionally, the
study explores regioselectivity, gram-scale reactions, and follow-up
transformations, underscoring the method’s potential.