NGF serum levels variations in major depressed patients receiving duloxetine

Neurotrophic factors in women with crack cocaine dependence during early abstinence: the role of early life stress

“…A clinical study reported elevated NGF levels in older healthy participants exposed to chronic stress, 60 whereas other studies on major depression reported lower serum levels of NGF. [61][62][63] On the other hand, peripheral GDNF was found to be increased in patients with late-onset depression compared with controls, 64 whereas other studies found GDNF to be decreased in individuals with major depression. 65 In addition, reduced expression of GDNF and NT-3 mRNA of peripheral blood cells in patients with major depression were associated with depressive state, 66 whereas increased cerebrospinal fluid levels of NT-3 were found in elderly patients with major depression.…”

“…However, we did not find any significant effect of comorbid psychiatric disorders on NF levels. Third, some of the women with crack dependence were using neuroleptics, mood stabilizers or antidepressants, and use of these medications can impact the levels of some NFs, 62,73 which could partially explain the NF changes that we found. It should be noted that the 2 groups of women with crack depend ence were homogeneously treated with common medications, and we did not find any significant differences between the experimental groups regarding the use of these medications.…”

Harm avoidance involved in mediating the association between nerve growth factor (NGF) gene polymorphisms and antidepressant efficacy in patients with major depressive disorder

“…On the other hand, the change of NGF expression after using antidepressant is more important than its usual expression (Overstreet et al, 2010). However, studies investigating the change of serum NGF levels in depressed patients receiving antidepressants treatment Martino et al, 2013;Liu et al, 2014) or electroconvulsive therapy (Gronli et al, 2009), have shown inconsistent results. Our results suggest that the antidepressants yield efficacy may through regulation of NGF gene even after controlling the age as a confounder.…”

“…Antidepressant could increase the expression Contents lists available at ScienceDirect journal homepage: www.elsevier.com/locate/jad of NGF in the limbic system (Jiang and Salton, 2013), particularly in the hippocampus (Malberg et al, 2000). Conversely, the serum NGF levels decreased in patients treated with duloxetine (Martino et al, 2013) and were unchanged in patients treated with electroconvulsive therapy (Gronli et al, 2009). Hence, NGF may be involved in the pathophysiology of major depressive disorder (MDD), as well as the response to antidepressant treatment.…”

Nerve Growth Factor(s) Mediated Hypothalamic Pituitary Adrenal Axis Dysregulation Model in Stress Induced Genesis of Psychiatric Disorders

“…There is ample evidence for involvement of prototype NGF and BDNF in development of schizophrenia (82)(83)(84), bipolar illness (37,85), depression (86,87), obsessive-compulsive disorder (OCD) (88)(89)(90), post traumatic stress disorder (PTSD) (91,92), eating disorders (93), conversion disorder (94), anxiety and aggression (57,83,95) and social defeat induced avoidance behaviour (77). Many studies reported NGFs' involvement in psychopathology of suicidal behaviour (96-98).…”