NGF induces appearance of adult-like response to spatial novelty in 18-day male mice

How to learn places without spatial concepts: Does the what-and-where reaction time system in children regulate learning during stimulus repetition?

“…This converges with earlier conceptions in cognitive psychology whereby unified object files hold various information such as color, shape and place (Treisman, 1993(Treisman, , 2006. Place memory may be more resource-intensive, but responds well to support: An application of the nerve growth factor improved place memory only in young rats (Calamandrei, Valanzano, & Ricceri, 2002). Likewise, methamphetamine was found to speed up place recognition in the what-and-where system, but disrupted object recognition (Bisagno, Ferguson, & Luine, 2002).…”

Developmental onset distinguishes three types of spontaneous recognition memory in mice

“…The lack of correlation between total exploration and discrimination index suggests that exploration is not a primary factor limiting performance in young C57/129J mice. Consistent with previous studies 16,41,43 , we also did not observe sex differences in any of our tasks. To our knowledge, sex differences in recognition memory in mice 44 and rats 45 have mostly been reported in animals at older ages, suggesting male and female mice may perform equally in spontaneous object recognition tests within the juvenile period.…”

Gender-dependent Association of a Functional NGF Polymorphism with Anxiety-related Personality Traits

“…Concerning serum concentrations of NGF, no main genderdependent diff erences have been observed [23,43] but in female human saliva increased concentrations have been found [29] . Moreover, NGF in peripheral organs has been shown to be highly dependent on estrogen and progesterone concentrations [8] and regulates behaviour in mice in a gender-dependent way [9] . Sex diff erences in nerve growth factor levels have been observed also in superior cervical ganglia and pineals [40] , corroborating a role of NGF as key sympathetic neurotrophin.…”