NG2-glia: rising stars in stress-related mental disorders?

Poggi, Giulia; Wennström, Malin; Müller, Marianne B.; Treccani, Giulia

doi:10.1038/s41380-022-01838-7

Cited by 7 publications

(8 citation statements)

References 18 publications

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“…NG2-glia are heterogeneous glial cells with distinct properties whose dysfunction can affect neuronal plasticity, leading to neurological and behavioral consequences [ 134 ]. Regarding the latter, the role of NG2 cells in stress-related mental disorders was recently reviewed [ 243 ]. It was concluded that dissecting the complex biology of NG2 glial cells and delineating their causal role in stress-related psychopathologies and stress response may provide novel interventions in such behavioral disorders [ 243 ].…”

Section: Nachrs–ng2 Cellsmentioning

confidence: 99%

“…Regarding the latter, the role of NG2 cells in stress-related mental disorders was recently reviewed [ 243 ]. It was concluded that dissecting the complex biology of NG2 glial cells and delineating their causal role in stress-related psychopathologies and stress response may provide novel interventions in such behavioral disorders [ 243 ].…”

Section: Nachrs–ng2 Cellsmentioning

confidence: 99%

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Nicotinic Acetylcholine Receptors in Glial Cells as Molecular Target for Parkinson’s Disease

Soares,

Costa,

Ferrolho

et al. 2024

Cells

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Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by resting tremor, bradykinesia, rigidity, and postural instability that also includes non-motor symptoms such as mood dysregulation. Dopamine (DA) is the primary neurotransmitter involved in this disease, but cholinergic imbalance has also been implicated. Current intervention in PD is focused on replenishing central DA, which provides remarkable temporary symptomatic relief but does not address neuronal loss and the progression of the disease. It has been well established that neuronal nicotinic cholinergic receptors (nAChRs) can regulate DA release and that nicotine itself may have neuroprotective effects. Recent studies identified nAChRs in nonneuronal cell types, including glial cells, where they may regulate inflammatory responses. Given the crucial role of neuroinflammation in dopaminergic degeneration and the involvement of microglia and astrocytes in this response, glial nAChRs may provide a novel therapeutic target in the prevention and/or treatment of PD. In this review, following a brief discussion of PD, we focus on the role of glial cells and, specifically, their nAChRs in PD pathology and/or treatment.

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Section: Nachrs–ng2 Cellsmentioning

confidence: 99%

Section: Nachrs–ng2 Cellsmentioning

confidence: 99%

Nicotinic Acetylcholine Receptors in Glial Cells as Molecular Target for Parkinson’s Disease

Soares,

Costa,

Ferrolho

et al. 2024

Cells

View full text Add to dashboard Cite

show abstract

“…NG2-glia are heterogeneous glial cells with distinct properties whose dysfunction can affect neuronal plasticity, leading to neurological and behavioral consequences [134]. Regarding the latter, the role of NG2 cells in stress-related mental disorders was recently reviewed [243]. It was concluded that dissecting the complex biology of NG2 glial cells and delineating their causal role in stressrelated psychopathologies and stress response may provide novel interventions in such behavioral disorders [243].…”

Section: Nachrs -Ng2 Cellsmentioning

confidence: 99%

“…Regarding the latter, the role of NG2 cells in stress-related mental disorders was recently reviewed [243]. It was concluded that dissecting the complex biology of NG2 glial cells and delineating their causal role in stressrelated psychopathologies and stress response may provide novel interventions in such behavioral disorders [243].…”

Section: Nachrs -Ng2 Cellsmentioning

confidence: 99%

Nicotinic Acetylcholine Receptors in Glial Cells as Molecular Target for Parkinson’s Disease

Soares,

Costa,

Ferrolho

et al. 2024

Preprint

View full text Add to dashboard Cite

Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by resting tremor, bradykinesia, rigidity, postural instability, that also includes non-motor symptoms such as mood dysregulation. Dopamine (DA) is the primary neurotransmitter involved in this disease, but cholinergic imbalance has also been implicated. Current intervention in PD is focused on replenishing central DA, which provides remarkable temporary symptomatic relief but does not address the neuronal loss and the progression of the disease. It has been well established that neuronal nicotinic cholinergic receptors (nAChRs) can regulate DA release and that nicotine itself may have neuroprotective effects. Recent studies have identified nAChRs in nonneuronal cell types including glial cells, where they may regulate inflammatory responses. Given the crucial role of neuroinflammation in dopaminergic degeneration, and the involvement of microglia and astrocytes in this response, glial nAChRs may provide a novel therapeutic target in prevention and/or treatment of PD. In this review, following a brief discussion of PD, we focus on the role of glial cells and specifically their nAChRs in PD pathology and/or treatment.

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“…NG2-glia are heterogeneous glial cells with distinct roles in neuronal plasticity, dysfunction of which can lead to neurological and behavioral consequences [209]. Indeed, the influence of NG2 cells in stress-induced mental disorders including depressive-like behavior, was recently highlighted [210]. It was concluded that further probe of a causal role of NG2 cells in stress response and stressrelated psychopathologies would be required before novel interventions in such behavioral disorders can be recommended [210].…”

Section: Ng2 Cells -Depressionmentioning

confidence: 99%

Role of Glial Cells in Depression and Drug Addiction

Tizabi,

Getachew,

Hauser

et al. 2024

Preprint

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Major depressive disorder (MDD) and substance use disorder (SUD) are of immense medical and social concerns. Although significant progress on neuronal involvement in mood and reward circuitries has been achieved, only relatively recently the role of glia in these disorders have attracted attention. Detail understanding of the glial function in these devastating diseases could offer novel interventions. Here, following a brief review of circuitries involved in mood regulation and reward perception, specific contribution of the neurotrophic factors, neuroinflammation and gut microbiota to these diseases are highlighted. In this context, the role of specific glial cells (e.g., microglia, astroglia, oligodendrocytes and synantocytes) on phenotypic manifestation of MDD or SUD are emphasized. In addition, potential use of this knowledge in developing novel therapeutics is touched upon.

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NG2-glia: rising stars in stress-related mental disorders?

Cited by 7 publications

References 18 publications

Nicotinic Acetylcholine Receptors in Glial Cells as Molecular Target for Parkinson’s Disease

Nicotinic Acetylcholine Receptors in Glial Cells as Molecular Target for Parkinson’s Disease

Nicotinic Acetylcholine Receptors in Glial Cells as Molecular Target for Parkinson’s Disease

Role of Glial Cells in Depression and Drug Addiction

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