NFκB inhibition decreases hepatocyte proliferation but does not alter apoptosis in obstructive jaundice

Ethyl Pyruvate Prevents Intestinal Inflammatory Response and Oxidative Stress in a Rat Model of Extrahepatic Cholestasis

“…This was consistent with the most recent study [12]. NF-kB is required for hepatocyte proliferation [32]. Yang et al [12] believed that ethyl pyruvate might inhibit activation of the NF-kB pathway in hepatic Kupffer cells but promote NF-kB activation in hepatocytes, and down-regulation of NF-kB signaling by EP in Kupffer cells could be masked by an opposite effect in hepatocytes.…”

Molecular and cellular features of hepatic regeneration

“…In rats with both bile duct and portal vein ligation, decreased HGF release was evident with subsequent poor regeneration [81]. Furthermore, in a bile duct ligated cholestatic rat model in which NFB was inhibited by an adenovirus expressing a mutated IB and a subsequent two-thirds partial hepatectomy was performed, DNA synthesis was impaired, while apoptosis was unchanged [82]. These findings suggest that NFB preferentially promotes DNA synthesis in the cholestatic liver.…”

The NF-κB inhibitors attenuate hepatic injury in bile duct ligated rats

“…In contrast, other studies demonstrated the induction of apoptosis by PDTC in different cell types, such as hepatocytes, thymocytes, smooth muscle cells, or murine B cells [32][33][34][35]. It has also been shown that NF-jB inhibition did not alter hepatocyte apoptosis in obstructive jaundice [36]. Although the protective action is mainly attributed to antioxidative properties of PDTC, it has been demonstrated that PDTC dose dependently reduced the cell number and viability [37].…”