NFkappaB is a Key Player in the Crosstalk between Inflammation and Cardiovascular Diseases

Fiordelisi, Antonella; Iaccarino, Guido; Morisco, Carmine; Coscioni, Enrico; Sorriento, Daniela

doi:10.3390/ijms20071599

Cited by 158 publications

(123 citation statements)

References 135 publications

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“…Recent studies have proposed a key role of inflammation in the determination of cardiovascular risk [28]. Levels of inflammatory cytokines are elevated in HF patients and related to an adverse outcome [29]. Activation of the immune system following cardiac injury is, per se, a protective (i.e., physiological) mechanism.…”

Section: Discussionmentioning

confidence: 99%

Neopterin is Associated with Disease Severity and Outcome in Patients with Non-Ischaemic Heart Failure

Lanser

Pölzl

Fuchs

et al. 2019

JCM

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Inflammation and immune activation play an important role in the pathogenesis of cardiac remodelling in patients with heart failure. The aim of this study was to assess whether biomarkers of inflammation and immune activation are linked to disease severity and the prognosis of heart failure patients. In 149 patients (65.8% men, median age 49.7 years) with heart failure from nonischaemic cardiomyopathy, the biomarkers neopterin and C-reactive protein were tested at the time of diagnosis. Patients were followed-up for a median of 58 months. During follow-up, nineteen patients died, five had a heart transplantation, two needed a ventricular assistance device, and twenty-one patients had to be hospitalised because of heart failure decompensation. Neopterin concentrations correlated with N-terminal prohormone of brain natriuretic peptide (NT-proBNP) concentrations (rs = 0.399, p < 0.001) and rose with higher New York Heart Association (NYHA) class (I: 5.60 nmol/L, II: 6.90 nmol/L, III/IV: 7.80 nmol/L, p = 0.033). Higher neopterin levels were predictive for an adverse outcome (death or hospitalisation due to HF decompensation), independently of age and sex and of established predictors in heart failure such as NYHA class, NT-proBNP, estimated glomerular filtration rate (eGFR), and left ventricular ejection fraction (LV-EF) (HR 2.770; 95% CI 1.419–5.407; p = 0.003). Patients with a neopterin/eGFR ratio ≥ 0.133 (as a combined marker for immune activation and kidney function) had a more than eightfold increased risk of reaching an endpoint compared to patients with a neopterin/eGFR ratio ≤0.065 (HR 8.380; 95% CI 2.889–24.308; p < 0.001). Neopterin is associated with disease severity and is an independent predictor of prognosis in patients with heart failure.

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Section: Discussionmentioning

confidence: 99%

Neopterin is Associated with Disease Severity and Outcome in Patients with Non-Ischaemic Heart Failure

Lanser

Pölzl

Fuchs

et al. 2019

JCM

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“…CVD are the leading cause of death in the world. These diseases affect the structure and/or function of the heart and blood vessels, and include highly prevalent disorders such as hypertension, atherosclerosis and myocardial infarction, among others [1,4,109,110]. Several metabolic risk factors involved in the development of CVD, such as hypercholesterolemia and diabetes promote EC dysfunction [4,109,111]…”

Section: Cardiovascular and Metabolic Diseasesmentioning

confidence: 99%

Use of Human Umbilical Vein Endothelial Cells (HUVEC) as a Model to Study Cardiovascular Disease: A Review

et al. 2020

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Cardiovascular disease (CVD) is the leading cause of death worldwide, and extensive research has been performed to understand this disease better, using various experimental models. The endothelium plays a crucial role in the development of CVD, since it is an interface between bloodstream components, such as monocytes and platelets, and other arterial wall components. Human umbilical vein endothelial cell (HUVEC) isolation from umbilical cord was first described in 1973. To date, this model is still widely used because of the high HUVEC isolation success rate, and because HUVEC are an excellent model to study a broad array of diseases, including cardiovascular and metabolic diseases. We here review the history of HUVEC isolation, the HUVEC model over time, HUVEC culture characteristics and conditions, advantages and disadvantages of this model and finally, its applications in the area of cardiovascular diseases.

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“…NF-κB is an aggregative name for inducible dimeric transcription factors, which are considered the main factors in inflammatory responses following multiple diseases. 7 , 8 RelA/p65 is one of the main subunits of NF-κB. 9 When the NF-κB signal is activated, the expression level of p65 and its move into the nucleus acts as a crucial role in the progress of inflammation during liver I/R injury.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of microRNA-128-3p alleviates liver ischaemia–reperfusion injury in mice through repressing the Rnd3/NF‐κB axis

et al. 2020

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Although liver ischaemia–reperfusion (I/R) injury remains the primary underlying reason for liver transplant failure or post-transplantation liver dysfunction, the underlying mechanism is still largely elusive. MicroRNAs (miRNA) are involved in multiple physiological and pathological processes, including inflammation. Here, we identified that the miR-128-3p/Rho family GTPase 3 (Rnd3)/NF‐κB axis might play a critical role in liver I/R injury. Our results demonstrated that the level of miR-128-3p was negatively correlated with the Rnd3 level during liver I/R. Dual luciferase reporter assay results proved that Rnd3 mRNA was a direct target of miR-128-3p. Additionally, Western blotting and quantitative RT-PCR analyses revealed that knock-down of miR-128-3p could up-regulate Rnd3 mRNA and protein levels, thereby suppressing the NF-κB pathway through down-regulating NF‐κB p65. Consequently, the serum levels of NF-κB–associated inflammatory factors and aspartate aminotransferase/alanine aminotransferase were decreased. Moreover, overexpression of Rnd3 could reverse the activation of NF-κB caused by miR-128-3p agomir during liver I/R injury. Overall, our study results suggest that repression of miR-128-3p can alleviate liver I/R injury through the miR-128-3p/Rnd3/NF‐κB axis and may facilitate the development of novel protective approaches against liver I/R injury.

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NFkappaB is a Key Player in the Crosstalk between Inflammation and Cardiovascular Diseases

Cited by 158 publications

References 135 publications

Neopterin is Associated with Disease Severity and Outcome in Patients with Non-Ischaemic Heart Failure

Neopterin is Associated with Disease Severity and Outcome in Patients with Non-Ischaemic Heart Failure

Use of Human Umbilical Vein Endothelial Cells (HUVEC) as a Model to Study Cardiovascular Disease: A Review

Inhibition of microRNA-128-3p alleviates liver ischaemia–reperfusion injury in mice through repressing the Rnd3/NF‐κB axis

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