Abstract:The commitment of stem and progenitor cells toward specific hematopoietic lineages is tightly controlled by a number of transcription factors that regulate differentiation programs via the expression of lineage restricting genes. Nuclear factor one (NFI) transcription factors are important in regulating hematopoiesis and here we report an important physiological role of NFIX in B-and myeloid lineage commitment and differentiation. We demonstrate that NFIX acts as a regulator of lineage specification in the hae… Show more
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