NFATc4 knockout promotes neuroprotection and retinal ganglion cell regeneration after optic nerve injury
Joanna Mackiewicz,
Julia Tomczak,
Malwina Lisek
et al.
Abstract:Retinal ganglion cells (RGCs), neurons transmitting visual information via the optic nerve, fail to regenerate their axons after injury. The progressive loss of RGC function underlies the pathophysiology of glaucoma and other optic neuropathies, often leading to irreversible blindness. Therefore, there is an urgent need to identify the regulators of RGC survival and the regenerative program. In this study, we investigated the role of the family of transcription factors known as nuclear factor of activated T ce… Show more
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