NFAT3 is specifically required for TNF-α-induced cyclooxygenase-2 (COX-2) expression and transformation of Cl41 cells

Abstract

Journal of Cell Science 119 (14)Journal of Cell Science . Effects of IL-1beta, TNF-alpha, and macrophage migration inhibitory factor on prostacyclin synthesis in rat pulmonary artery smooth muscle cells.

Diabetic microangiopathy: Pathogenetic insights and novel therapeutic approaches

“…In addition, hypertonic saline has been reported to induce COX-2 in rat macrophages [87] and human ECs [88]. The participation of NFAT transcription factors in COX-2 activation was also already shown in several additional cell types [89][90][91][92][93][94]. In fact, previous research had shown that the angiogenic signaling involved in the induction of COX-2 by VEGF in human ECs requires the activation of NFAT proteins [91].…”

A JNK1/AP-1–Dependent, COX-2 Induction Is Implicated in 12-O-Tetradecanoylphorbol-13-Acetate–Induced Cell Transformation through Regulating Cell Cycle Progression

“…Although the implications of COX-2 in cell proliferation, cell transformation, and carcinogenesis have been evidential in most of the previous studies (4,20), there is still some evidence showing that COX is not involved in biological effects in some systems (38,39). For example, Lu et al (38) has reported that overexpressing human cDNA of COX-2 in human breast epithelial cells inhibited cell proliferation by delaying cell cycle progression through the G 1 phase.…”

“…The COX-2 -luciferase reporter plasmid containing the upstream 5 ¶-flanking region of the COX-2 gene promoter linked to the luciferase reporter was described in our previous studies (20). A pcDNA3.…”

“…The stable transfectants of COX-2 siRNA was identified in MEFs ( Fig. 2A) and in Cl41 cells (20). The soft agar assay was then carried out to measure the ability of cells to grow in an anchorage-independent manner promoted by TPA treatment.…”

Metabolomics and Transcriptional Responses in Estrogen Receptor Positive Breast Cancer Cells

“…MSK has also been implicated in cancer-related inflammation through COX2 expression. It has been observed that MSK-mediated COX2 expression in mouse epidermal cells induces neoplastic transformation (Yan et al, 2006). MSK recruitment and H3S10 and H3S28 phosphorylation occur at the upstream regulatory promoter region of COX2 in mouse fibroblasts in addition to the recruitment of chromatin remodeling factors and transcriptional activation histone marks at these sites (Drobic et al, 2010).…”