NF2 Gene Participates in Regulation of the Cell Cycle of Meningiomas by Restoring Spindle Assembly Checkpoint Function and Inhibiting the Binding of Cdc20 Protein to Anaphase Promoting Complex/Cyclosome

Ma, Mengyin; Ge, Yu; Zhang, Tao

doi:10.1016/j.wneu.2021.10.163

Cited by 2 publications

(2 citation statements)

References 52 publications

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“…Apart from that, cell cycle and systemic lupus erythematosus were revealed in the KEGG analysis. Cell cycle process has been proved that it has an important role in the development of meningioma 58 . And, some reports showed that systemic lupus erythematosus and meningioma happened in a patient 59,60 , which may reveal that progression of meningioma may involve in the immune process and reaction.…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors and Doxorubicin involved in malignant progression of meningioma

Huo

Song

Wang

et al. 2023

Sci Rep

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Meningioma was the most primary intracranial tumor, but the molecular characteristics and the treatment of malignant meningioma were still unclear. Nine malignant progression-related genes based prognostic signatures were identified by transcriptome analysis between benign meningioma and malignant meningioma. The external dataset GEO136661 and quantitative Real-time Polymerase Chain Reaction were used to verify the prognostic factors. has-miR-3605-5p, hsa-miR-664b-5p, PNRC2, BTBD8, EXTL2, SLFN13, DGKD, NSD2, and BVES were closed with malignant progression. Moreover, Doxorubicin was identified by Connectivity Map website with the differential malignant progression-related genes. CCK-8 assay, Edu assay, wound healing assay, and trans-well experiment were used to reveal that Doxorubicin could inhibit proliferation, migration and invasion of IOMM-Lee Cells.

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Section: Discussionmentioning

confidence: 99%

Prognostic factors and Doxorubicin involved in malignant progression of meningioma

Huo

Song

Wang

et al. 2023

Sci Rep

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“…[62] Furthermore, neurofibromatosis type 2 might restore spindle assembly checkpoint function by impairing the binding of APC/C and CDC20, thereby inhibiting meningioma proliferation. [37] The CDC20-APC/SOX2 signaling axis controls the key biological properties of glioma cells, and targeting this pathway in glioblastoma may dispute the glioblastoma stem-like cell line state. [40] In addition, hyperphosphorylation of CDH1 is a major mechanism that drives attenuated APC/CDC20 activity in the G1 phase of the cell cycle and reduces the viability of glioma cells.…”

Section: Role Of Cdc20 In Human Malignant Solid Tumorsmentioning

confidence: 99%

The potential role of CDC20 in tumorigenesis, cancer progression and therapy: A narrative review

Xian,

Zhao,

Huang

et al. 2023

Medicine

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The cell division cycle 20 homologue (CDC20) is known to regulate the cell cycle. Many studies have suggested that dysregulation of CDC20 is associated with various pathological processes in malignant solid tumors, including tumorigenesis, progression, chemoradiotherapy resistance, and poor prognosis, providing a biomarker for cancer diagnosis and prognosis. Some researchers have demonstrated that CDC20 also regulates apoptosis, immune microenvironment, and tumor angiogenesis. In this review, we have systematically summarized the biological functions of CDC20 in solid cancers. Furthermore, we briefly synthesized multiple medicines that inhibited CDC20. We anticipate that CDC20 will be a promising and effective biomarker and therapeutic target for the treatment of human cancer.

show abstract

NF2 Gene Participates in Regulation of the Cell Cycle of Meningiomas by Restoring Spindle Assembly Checkpoint Function and Inhibiting the Binding of Cdc20 Protein to Anaphase Promoting Complex/Cyclosome

Cited by 2 publications

References 52 publications

Prognostic factors and Doxorubicin involved in malignant progression of meningioma

Prognostic factors and Doxorubicin involved in malignant progression of meningioma

The potential role of CDC20 in tumorigenesis, cancer progression and therapy: A narrative review

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