NF‐κB1 promotes miR‐27a‐5p upregulation in acrylamide‐induced toxicity in rats
Lujia Zhang,
Liuqing Yang,
Jianwei Gao
et al.
Abstract:Acrylamide (AA) is a neurotoxic and potentially carcinogenic contaminant, usually generated during food processing. MicroRNAs are a class of noncoding small RNAs, which serve essential pathogenic roles in linking exposure to toxic contaminants with their pathological outcomes. Our previous research identified miR‐27a‐5p as a key regulator in AA toxicity, as it induces mitochondria‐dependent apoptosis by targeting Btf3 in rats. However, the mechanisms by which miR‐27a‐5p is regulated to exert its toxic effects … Show more
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