NF-κB-mediated lncRNA AC007271.3 promotes carcinogenesis of oral squamous cell carcinoma by regulating miR-125b-2-3p/Slug

Zheng, Zenan; Huang, Guangzhao; Wu, Qimeng; Ye, Heng-Yu; Zeng, Weisen; Lv, Xiaoyang

doi:10.1038/s41419-020-03257-4

Cited by 15 publications

(12 citation statements)

References 45 publications

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“…Aberrant expression of lncRNAs has been observed in human cancers, where they can act as either tumor suppressor genes or oncogenes, depending on the environment in which tumor cells are located ( 9 , 10 ). Multiple studies have shown that the dysregulation of lncRNAs is extensively involved in the malignant progression of human cancers ( 11 , 12 ). In addition, lncRNAs also play a crucial role in the occurrence and development of glioma.…”

Section: Introductionmentioning

confidence: 99%

A Signature of Nine lncRNA Methylated Genes Predicts Survival in Patients With Glioma

et al. 2021

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Glioma is one of the most common malignant tumors of the central nervous system, and its prognosis is extremely poor. Aberrant methylation of lncRNA promoter region is significantly associated with the prognosis of glioma patients. In this study, we investigated the potential impact of methylation of lncRNA promoter region in glioma patients to establish a signature of nine lncRNA methylated genes for determining glioma patient prognosis. Methylation data and clinical follow-up data were obtained from The Cancer Genome Atlas (TCGA). The multistep screening strategy identified nine lncRNA methylated genes that were significantly associated with the overall survival (OS) of glioma patients. Subsequently, we constructed a risk signature that containing nine lncRNA methylated genes. The risk signature successfully divided the glioma patients into high-risk and low-risk groups. Compared with the low-risk group, the high-risk group had a worse prognosis, higher glioma grade, and older age. Furthermore, we identified two lncRNAs termed PCBP1-AS1 and LINC02875 that may be involved in the malignant progression of glioma cells by using the TCGA database. Loss-of-function assays confirmed that knockdown of PCBP1-AS1 and LINC02875 inhibited the proliferation, migration, and invasion of glioma cells. Therefore, the nine lncRNA methylated genes signature may provide a novel predictor and therapeutic target for glioma patients.

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Section: Introductionmentioning

confidence: 99%

A Signature of Nine lncRNA Methylated Genes Predicts Survival in Patients With Glioma

et al. 2021

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“…The NF‐κB promotes lncRNA AC007271.3 expression to reduce miRNA‐125b‐23p expression via sponging. Then, an increase occurs in Slug expression and mediates EMT in oral tumor metastasis (Zheng et al, 2020). Therefore, lncRNAs are potential modulators of the NF‐κB/EMT axis in various cancers.…”

Section: Ncrnas In Nf‐κb/emt Regulationmentioning

confidence: 99%

NF‐κB as a regulator of cancer metastasis and therapy response: A focus on epithelial–mesenchymal transition

Mirzaei

Saghari

Bassiri

et al. 2022

Journal Cellular Physiology

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Metastasis of tumor cells is a complex challenge and significantly diminishes the overall survival and prognosis of cancer patients. The epithelial‐to‐mesenchymal transition (EMT) is a well‐known mechanism responsible for the invasiveness of tumor cells. A number of molecular pathways can regulate the EMT mechanism in cancer cells and nuclear factor‐kappaB (NF‐κB) is one of them. The nuclear translocation of NF‐κB p65 can induce the transcription of several genes involved in EMT induction. The present review describes NF‐κB and EMT interaction in cancer cells and their association in cancer progression. Due to the oncogenic role NF‐κB signaling, its activation enhances metastasis of tumor cells via EMT induction. This has been confirmed in various cancers including brain, breast, lung and gastric cancers, among others. The ZEB1/2, transforming growth factor‐β, and Slug as inducers of EMT undergo upregulation by NF‐κB to promote metastasis of tumor cells. After EMT induction driven by NF‐κB, a significant decrease occurs in E‐cadherin levels, while N‐cadherin and vimentin levels undergo an increase. The noncoding RNAs can potentially also function as upstream mediators and modulate NF‐κB/EMT axis in cancers. Moreover, NF‐κB/EMT axis is involved in mediating drug resistance in tumor cells. Thus, suppressing NF‐κB/EMT axis can also promote the sensitivity of cancer cells to chemotherapeutic agents.

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“…Of note, circSND1 elevation could in turn activate NF-κB pathway through miR-125a-3p/FUT6 axis which promoted the nucleus accumulation of p65, hence establishing a positive regulatory circuit that reciprocally stimulated inflammation and the malignant progression of cervical cancer [ 90 ]. Similarly, the increased expression of miR-130a in cervical cancer [ 91 ], upregulated lncRNA AC007271.3 in oral squamous cell carcinoma [ 92 ], and induced lncRNA HOTAIR expression in several human tumor entities [ 93 ] are also attributed to the activated TNF-α/NF-κB signaling cascade under inflammatory stimuli. Alternatively, studies have observed the TNF-α/STAT3 axis in the upregulation of various lncRNAs like LOC105374902.…”

Section: Ncrnas Regulated By Inflammationmentioning

confidence: 99%

Noncoding RNAs as sensors of tumor microenvironmental stress

Wang

et al. 2022

J Exp Clin Cancer Res

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The tumor microenvironment (TME) has been demonstrated to modulate the biological behavior of tumors intensively. Multiple stress conditions are widely observed in the TME of many cancer types, such as hypoxia, inflammation, and nutrient deprivation. Recently, accumulating evidence demonstrates that the expression levels of noncoding RNAs (ncRNAs) are dramatically altered by TME stress, and the dysregulated ncRNAs can in turn regulate tumor cell proliferation, metastasis, and drug resistance. In this review, we elaborate on the signal transduction pathways or epigenetic pathways by which hypoxia-inducible factors (HIFs), inflammatory factors, and nutrient deprivation in TME regulate ncRNAs, and highlight the pivotal roles of TME stress-related ncRNAs in tumors. This helps to clarify the molecular regulatory networks between TME and ncRNAs, which may provide potential targets for cancer therapy.

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NF-κB-mediated lncRNA AC007271.3 promotes carcinogenesis of oral squamous cell carcinoma by regulating miR-125b-2-3p/Slug

Cited by 15 publications

References 45 publications

A Signature of Nine lncRNA Methylated Genes Predicts Survival in Patients With Glioma

A Signature of Nine lncRNA Methylated Genes Predicts Survival in Patients With Glioma

NF‐κB as a regulator of cancer metastasis and therapy response: A focus on epithelial–mesenchymal transition

Noncoding RNAs as sensors of tumor microenvironmental stress

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