NF-κB-induced oxidative stress contributes to mitochondrial and cardiac dysfunction in type II diabetes

Mariappan, Nithya; Elks, Carrie M.; Sriramula, Srinivas; Guggilam, Anuradha; Liu, Zhizhen; Borkhsenious, Olga N.; Francis, Joseph

doi:10.1093/cvr/cvp305

Cited by 201 publications

(137 citation statements)

References 39 publications

(57 reference statements)

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“…It is known that NF-B activation is a key event for the initiation of cardiovascular pathogenesis in diabetes as a result of increased oxidative stress (56,57). We found that the protein levels of the NF-B1/p50 and p65 subunits were augmented in diabetic vessels and in HG-cultured human coronary SMCs.…”

Section: Discussionmentioning

confidence: 62%

Regulation of Large Conductance Ca2+-activated K+ (BK) Channel β1 Subunit Expression by Muscle RING Finger Protein 1 in Diabetic Vessels

Wang

Chai

et al. 2014

Journal of Biological Chemistry

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Background: Impaired BK channel function in diabetic vessels is associated with decreased BK channel ␤1 subunit (BK-␤1) expression. Results: Muscle RING finger protein 1 (MuRF1) physically interacts with BK-␤1 and accelerates BK-␤1 proteolysis. Conclusion: Increased MuRF1 expression is a novel mechanism underlying diabetic BK channelopathy and vasculopathy. Significance: MuRF1 is a potential therapeutic target of BK channel dysfunction and vascular complications in diabetes.

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Section: Discussionmentioning

confidence: 62%

Regulation of Large Conductance Ca2+-activated K+ (BK) Channel β1 Subunit Expression by Muscle RING Finger Protein 1 in Diabetic Vessels

Wang

Chai

et al. 2014

Journal of Biological Chemistry

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“…These results indicated that mitochondrial energetics were impaired in the heart of db/db mice. Mariappan and coworkers discovered that nuclear factor kappa-B (NF-κB) induced oxidative stress and contributed to mitochondrial and cardiac dysfunction in db/db mice (Mariappan et al, 2009). Mitochondrial abnormality was also observed in T1DM Akita mouse hearts (Bugger et al, 2008).…”

Section: Heartmentioning

confidence: 99%

Mitochondria in the pathogenesis of diabetes: a proteomic view

2012

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Diabetes mellitus is a complex metabolic disorder characterized by chronic hyperglycemia due to absolute or relative lack of insulin. Though great efforts have been made to investigate the pathogenesis of diabetes, the underlying mechanism behind the development of diabetes and its complications remains unexplored. Cumulative evidence has linked mitochondrial modification to the pathogenesis of diabetes and its complications and they are also observed in various tissues affected by diabetes. Proteomics is an attractive tool for the study of diabetes since it allows researchers to compare normal and diabetic samples by identifying and quantifying the differentially expressed proteins in tissues, cells or organelles. Great progress has already been made in mitochondrial proteomics to elucidate the role of mitochondria in the pathogenesis of diabetes and its complications. Further studies on the changes of mitochondrial protein specifically post-translational modifications during the diabetic state using proteomic tools, would provide more information to better understand diabetes.

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“…For example SF inhibits NF-κB transcription in many cancer models (Srivastava & Singh, 2004;Xu C, 2005). Activation of NF-κB, an upstream regulator of many inflammatory cytokines, has also been well linked to insulin resistance and diabetes (Mariappan et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Stable, water extractable isothiocyanates from Moringa oleifera leaves attenuate inflammation in vitro

Waterman¹,

Cheng²,

Rojas-Silva³

et al. 2014

Planta Med

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Moringa (Moringa oleifera Lam.) is an edible plant used as food and medicine throughout the tropics. A moringa concentrate (MC) made by extracting fresh leaves with water utilized naturally occurring myrosinase to convert four moringa glucosinolates (1-4) into moringa isothiocyanates (5-8). Optimum conditions maximizing MC yield, compound 5 (4-[(α-Lrhamnosyloxy)benzyl]isothiocyanate), and compound 8 (4-[(4'-O-acetyl-α-Lrhamnosyloxy)benzyl]isothiocyanate) content were established (1:5 fresh leaf weight to water ratio at room temperature). The optimized MC contained 1.66% isothiocyanates and 3.82% total polyphenols. Compound 8 exhibited 80% stability at 37 °C for 30 days. MC, 5, and 8 significantly decreased gene expression and production of inflammatory markers in RAW macrophages. Specifically, 5 and 8 attenuated expression of iNOS and IL-1β and production of nitric oxide and TNFβ at 1 and 5 µM. Our results suggest a potential for stable and concentrated moringa isothiocyanates (5-8), delivered in MC as a food-grade product, to alleviate low-grade inflammation associated with chronic diseases.

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NF-κB-induced oxidative stress contributes to mitochondrial and cardiac dysfunction in type II diabetes

Cited by 201 publications

References 39 publications

Regulation of Large Conductance Ca2+-activated K+ (BK) Channel β1 Subunit Expression by Muscle RING Finger Protein 1 in Diabetic Vessels

Regulation of Large Conductance Ca2+-activated K+ (BK) Channel β1 Subunit Expression by Muscle RING Finger Protein 1 in Diabetic Vessels

Mitochondria in the pathogenesis of diabetes: a proteomic view

Stable, water extractable isothiocyanates from Moringa oleifera leaves attenuate inflammation in vitro

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