NF-κB in Renal Inflammation

The C-terminal module IV of connective tissue growth factor is a novel immune modulator of the Th17 response

“…42 Among the intracellular signaling systems involved in the pathogenesis of renal inflammation, the activation of the NF-kB pathway has special interest. 43 In CCN2(IV)-treated mice, elevated renal mRNA and protein levels of MCP-1 and RANTES were found at all time points studied (real-time PCR and ELISA; Figures 4a and b). Moreover, in renal nuclear protein extracts of CCN2(IV)-treated mice, elevated levels of p65 NF-kB subunit were observed as compared with controls (Figure 4c), demonstrating renal NF-kB activation.…”

Hydrogen Sulfide Alleviates Diabetic Nephropathy in a Streptozotocin-induced Diabetic Rat Model

“…NF-B activation has been documented to be associated with renal inflammation (14). In the classical pathway of NF-B activation, phosphorylation of IB by the activated IB kinase complex leads to proteolysis of the NF-B-bound IB.…”

Interleukin-10 deficiency aggravates kidney inflammation and fibrosis in the unilateral ureteral obstruction mouse model

“…These results are also consistent with previous studies suggesting IL-10 mediates anti-inflammation and anti-fibrotic effects through negatively regulating these signaling pathways. [38][39][40][41][42][43][44] It has been shown that the treatment with IL-10 could inhibit TGF-b and NF-kB activation to reduce inflammatory response, ECM production and fibrotic genes expression in animal models of pulmonary and hepatic fibrosis. 34,45 In summary, the present study suggests that the deficiency of IL-10 aggravates inflammation and fibrosis in obstructive kidney disease.…”