NF-κB in Cell Deaths, Therapeutic Resistance and Nanotherapy of Tumors: Recent Advances

Wu, Xuesong; Sun, Liang; Xu, F.

doi:10.3390/ph16060783

Cited by 7 publications

(2 citation statements)

References 165 publications

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“…NF-κB is a transcription factor that plays important roles in cellular functions such as proliferation, differentiation, and apoptosis [75]. Currently, there is substantial evidence pointing to the dual role of NF-κB in cancer [76]. There was a favorable interaction between EZ and NF-κB, with amino acid residues involved in this binding also participating in the interaction between DXR and NF-κB (Cys120, Arg187, and Tyr36).…”

Section: Discussionmentioning

confidence: 99%

The Essential Oil from Conyza bonariensis (L.) Cronquist (Asteraceae) Exerts an In Vitro Antimelanoma Effect by Inducing Apoptosis and Modulating the MAPKs, NF-κB, and PKB/AKT Signaling Pathways

Ferreira,

Duarte,

de Sousa

et al. 2023

Pharmaceuticals

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The characterization and cytotoxicity of the essential oil from Conyza bonariensis (L.) aerial parts (CBEO) were previously conducted. The major compound was (Z)-2-lachnophyllum ester (EZ), and CBEO exhibited significant ROS-dependent cytotoxicity in the melanoma cell line SK-MEL-28. Herein, we employed the Molegro Virtual Docker v.6.0.1 software to investigate the interactions between the EZ and Mitogen-Activated Protein Kinases (MAPKs), the Nuclear Factor kappa B (NF-κB), and the Protein Kinase B (PKB/AKT). Additionally, in vitro assays were performed in SK-MEL-28 cells to assess the effect of CBEO on the cell cycle, apoptosis, and these signaling pathways by flow cytometry and the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay using MAPKs inhibitors. CBEO induced a significant increase in the sub-G1 peak, as well as biochemical and morphological changes characteristic of apoptosis. The in-silico results indicated that EZ interacts with Extracellular Signal-Regulated Kinase 1 (ERK1), c-Jun N-terminal Kinase 1 (JNK1), p38α MAPK, NF-κB, and PKB/AKT. Moreover, CBEO modulated the ERK1/2, JNK, p38 MAPK, NF-κB, and PKB/AKT activities in SK-MEL-28 cells. Furthermore, CBEO’s cytotoxicity against SK-MEL-28 cells was significantly altered in the presence of MAPKs inhibitors. These findings support the in vitro antimelanoma effect of CBEO through apoptosis induction, and the modulation of ERK, JNK, p38 MAPK, NF-κB, and PKB/AKT activities.

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Section: Discussionmentioning

confidence: 99%

The Essential Oil from Conyza bonariensis (L.) Cronquist (Asteraceae) Exerts an In Vitro Antimelanoma Effect by Inducing Apoptosis and Modulating the MAPKs, NF-κB, and PKB/AKT Signaling Pathways

Ferreira,

Duarte,

de Sousa

et al. 2023

Pharmaceuticals

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“…Similarly, it has been verified that CAFs exhibit elevated levels of pro-inflammatory factors and can secrete signaling molecules (e.g., IL-8 and HMGB1) that activate the NF-κB pathway in neighboring cancer cells [ 137 – 139 ]. Notably, NF-κB activation is intricately related to inflammasome signaling and has the potential to mediate the expression of genes associated with pyroptosis [ 140 , 141 ]. Furthermore, Chalkidi et al analyzed the transcriptomic profile of CAFs in colitis-associated cancer and revealed the significant enrichment pathways in pyroptosis within CAFs [ 142 ].…”

Section: Effects Of Cafs On Tumor Pyroptosismentioning

confidence: 99%

Crosstalk between cancer-associated fibroblasts and regulated cell death in tumors: insights into apoptosis, autophagy, ferroptosis, and pyroptosis

Chen,

Liu,

Lin

et al. 2024

Cell Death Discov.

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Cancer-associated fibroblasts (CAFs), the main stromal component of the tumor microenvironment (TME), play multifaceted roles in cancer progression through paracrine signaling, exosome transfer, and cell interactions. Attractively, recent evidence indicates that CAFs can modulate various forms of regulated cell death (RCD) in adjacent tumor cells, thus involving cancer proliferation, therapy resistance, and immune exclusion. Here, we present a brief introduction to CAFs and basic knowledge of RCD, including apoptosis, autophagy, ferroptosis, and pyroptosis. In addition, we further summarize the different types of RCD in tumors that are mediated by CAFs, as well as the effects of these modes of RCD on CAFs. This review will deepen our understanding of the interactions between CAFs and RCD and might offer novel therapeutic avenues for future cancer treatments.

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NFκB signalling in colorectal cancer: Examining the central dogma of IKKα and IKKβ signalling

McKenzie,

Lian,

Pennel

et al. 2024

Heliyon

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NF-κB in Cell Deaths, Therapeutic Resistance and Nanotherapy of Tumors: Recent Advances

Cited by 7 publications

References 165 publications

The Essential Oil from Conyza bonariensis (L.) Cronquist (Asteraceae) Exerts an In Vitro Antimelanoma Effect by Inducing Apoptosis and Modulating the MAPKs, NF-κB, and PKB/AKT Signaling Pathways

The Essential Oil from Conyza bonariensis (L.) Cronquist (Asteraceae) Exerts an In Vitro Antimelanoma Effect by Inducing Apoptosis and Modulating the MAPKs, NF-κB, and PKB/AKT Signaling Pathways

Crosstalk between cancer-associated fibroblasts and regulated cell death in tumors: insights into apoptosis, autophagy, ferroptosis, and pyroptosis

NFκB signalling in colorectal cancer: Examining the central dogma of IKKα and IKKβ signalling

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