NF-κB expression and its association with nutritional status in hemodialysis patients

Farage, Najla Elias; Stockler‐Pinto, Milena Barcza; Leal, Viviane O.; Cardozo, Ludmila F M F; Carraro-Eduardo, José Carlos; Fouque, Denis

doi:10.1007/s11255-016-1425-6

Cited by 5 publications

(3 citation statements)

References 32 publications

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“…Activation of NFkB via the UPS and the MuRF1 pathways induces muscle degradation and muscle wasting, which in turn induces cellular apoptosis [19]. Higher levels of NFkB have been observed in hemodialysis patients with poor nutritional status, reinforcing the hypothesis that inflammation is a key driver of PEW [34]. Furthermore, blocking the translocation to the nucleus by pharmacological or genetic inhibition of NFkB prevents the expression of several components of the proteolytic machinery including MuRF1, muscle synthesis and preservation [6].…”

Section: Ubiquitin-proteasome System: Nrf2 Signaling Pathway and Its ...mentioning

confidence: 97%

“…NRF2 deficiency may exacerbate age-related mitochondrial oxidative stress in aged skeletal muscle [ 46 ] and be part of an intermediate inflammatory phenotype that promotes burden of lifestyle diseases that accumulate with age [ 47 ]. The decrease in the number of fat-free myocytes and the low transcription of NRF2 [ 44 ] may be related to several factors, such as inadequate diet, hyperparathyroidism, depression, dementia, osteoporosis, periodontitis [ 43 ], dialysis, uremic toxins [ 48 ], obesity, hyperglycemia, variants of NFE2L2 gene (encoding NRF2 protein) [ 22 , 49 ], metabolic acidosis and endothelial dysfunction [ 23 , 34 ]. All these factors promote muscle degradation and may contribute to skeletal muscle dysfunction by inducing ubiquitination, lipid peroxidation and activation of apoptotic processes and autophagy with mediators such as calpain and caspases [ 18 ].…”

Section: Ubiquitin–proteasome System: Nrf2 Signaling Pathway and Its ...mentioning

confidence: 99%

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Transcription factor NRF2 as potential therapeutic target for preventing muscle wasting in aging chronic kidney disease patients

et al. 2022

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Increased muscle protein catabolism leading to muscle wasting is a prominent feature of the syndrome of protein-energy wasting (PEW) in patients with chronic kidney disease (CKD). PEW and muscle wasting are induced by factors such as inflammation, oxidative stress and metabolic acidosis that activate the ubiquitin–proteasome system, the main regulatory mechanism of skeletal muscle degradation. Whether deficiency of nuclear factor erythroid 2-related factor 2 (NRF2), which regulates expression of antioxidant proteins protecting against oxidative damage triggered by inflammation, may exacerbate PEW has yet to be examined in aging patients with CKD. This review focuses on the hypothesis that NRF2 is involved in the maintenance of muscle mass and explores whether sustained activation of NRF2 by non-pharmacological interventions using nutraceutical activators to improve redox homeostasis could be a plausible strategy to prevent skeletal muscle disorders, including muscle wasting, sarcopenia and frailty associated with PEW in aging CKD patients. Graphical abstract

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Section: Ubiquitin-proteasome System: Nrf2 Signaling Pathway and Its ...mentioning

confidence: 97%

Section: Ubiquitin–proteasome System: Nrf2 Signaling Pathway and Its ...mentioning

confidence: 99%

Transcription factor NRF2 as potential therapeutic target for preventing muscle wasting in aging chronic kidney disease patients

et al. 2022

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“…Eleven studies were eligible. One study investigated NRF2 in HD patients and found no correlation to biochemical and anthropometrical parameters [68].…”

Section: Relation Between Nrf2 Nqo1 and Ho-1 And Clinically Relevant ...mentioning

confidence: 99%

Systematic review of the nuclear factor erythroid 2-related factor 2 (NRF2) system in human chronic kidney disease: alterations, interventions and relation to morbidity

Juul-Nielsen

Shen

Stenvinkel

et al. 2021

Nephrology Dialysis Transplantation

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Background NRF2 and its effectors NAD(P)H:quinoneoxidoreductase 1 (NQO1) and heme oxygenase 1 (HO-1) are of interest in kidney disease. We therefore reviewed studies about their status in patients with chronic kidney disease (CKD). Methods We undertook systematic searches of PubMed and EMBASE databases. Alterations of NRF2, NQO1 and HO-1 in CKD, their responses to interventions and their relation to clinically relevant parameters were reported. Results We identified 1373 articles, of which 32 studies met the inclusion criteria. NRF2 levels were decreased in the majority of analyses of CKD patients. Half of the analyses showed a similar or increased NQO1 level vs. control, whereas NQO1 was decreased in half of the analyses. Most of the studies reported either an increased or similar HO-1 level in CKD patients compared to controls. For patients with CKD stages 1-4, studies reported positive correlations to markers of kidney disease severity. Also, positive associations of NQO1/HO-1 levels to inflammation and comorbidities were reported. One third of the studies showed discordant changes between gene expression and protein level of NRF2 system components. Two thirds of intervention studies (50% dietary, such as using resistant starch) reported an increase of NRF2, NQO1, or HO-1. Conclusions In patients with CKD, NRF2 expression was downregulated, while NQO1 and HO-1 showed varying alterations related to inflammation, comorbidities, and severity of kidney damage. Interventions that increased NRF2 system components were described, but their effectiveness and clinical relevance require further clinical studies of high quality. Research on gene expression together with protein analyses is indispensable to understand NRF2 system alterations in CKD.

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Causes and treatment of protein-energy wasting in kidney disease

Sumida

Kövesdy

2022

Nutritional Management of Renal Disease

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NF-κB expression and its association with nutritional status in hemodialysis patients

Abstract: The classical NF-κB activation seems to be associated with poor nutritional status in HD patients; however, the exact underlying mechanisms deserve further studies.

Cited by 5 publications

References 32 publications

Transcription factor NRF2 as potential therapeutic target for preventing muscle wasting in aging chronic kidney disease patients

Transcription factor NRF2 as potential therapeutic target for preventing muscle wasting in aging chronic kidney disease patients

Systematic review of the nuclear factor erythroid 2-related factor 2 (NRF2) system in human chronic kidney disease: alterations, interventions and relation to morbidity

Causes and treatment of protein-energy wasting in kidney disease

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