NF-κB DNA binding activity of sesquiterpene lactones fromAnthemis arvensisandAnthemis cotula

Vučković, Ivan; Vujisić, Ljubodrag; Klaas, Christoph A.; Merfort, Irmgard; Milosavljević, Slobodan

doi:10.1080/14786410902941402

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…Essential oils from flowers Anthemis is very useful for pharmaceuticals, and food additives, as well as important sources in food, aromatic and cosmetic industries. The species Anthemis has been studied on the chemical composition and diverse biological activities, such as their antioxidant, antifungal, antiplasmodial, antitumor, schistosomicidal, cytotoxic, anthelmintic, phytotoxic, analgesic effects [16][17][18][19][20][21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

The Study of the Composition of the Extract and Antimycotic Properties Anthemis Altissima L.

Mustafayeva

Serkerov

2019

JCPRM

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The qualitative and quantitative composition of chemical components of ethanol extract of the above-ground part of Anthemis altissima L. (syn. Cota altissima (L.) J.Gay) species (family Asteraceae) collected during flowering phase from the flora of Azerbaijan has been studied. The chemical composition of ethanol extract was analyzed by chromatography-mass-spectrometry methods. 54 components were identified in the extract. As a result of the study, it was found that the A. altissima contained benzene aromatic compounds (77.21%). Among them Benzene, (1-butylheptyl) – 7.84%, Benzene, (1-propyloctyl) – 7.71%, Benzene, (1-pentyloctyl) – 7.03%, Benzene, (1-pentylheptyl) – 5.69%, Benzene, (1-butyloctyl) – 5.37%, Benzene, (1-propylnonyl) – 5.02% were the main components. In addition to the above components in the extract of the aerial part other biological active substances, such as alcohols (6.37% – of them prevail Hop-22(29)-en-3. β.-ol – 1.53%, γ-Sitosterol – 1.32%), esters of acids (5.3% – of them prevail Hexadecanoic acid, ethyl ester – 0.88%; Linoleic acid, ethyl ester – 0.63%) and alkanes (1.64% – of them prevail Eicosane – 0.53%; Pentacosane – 0.40%) were also identified. The share of unidentified components was 8.99%. The article also presents the results of the study of the antifungal properties of A. altissima and its aqueous extract against the culture of pathogenic fungi Fusarium oxysporium and Aspergillus niger. The aqueous extract of A. altissima, in contrast to the plant itself, shows a fungistatic effect on the fungi Fusarium oxysporum and Aspergillus niger.

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Section: Introductionmentioning

confidence: 99%

The Study of the Composition of the Extract and Antimycotic Properties Anthemis Altissima L.

Mustafayeva

Serkerov

2019

JCPRM

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Antioxidant activities of eight Algerian plant extracts and two essential oils

Bakchiche

Gherib

Aazza

et al. 2013

Industrial Crops and Products

141

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Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions

et al. 2016

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Although Michael acceptors display a potent and broad spectrum of bioactivity, they have largely been ignored in drug discovery because of their presumed indiscriminate reactivity. As such, a dearth of information exists relevant to the thiol reactivity of natural products and their analogs possessing this moiety. In the midst of recently approved acrylamide-containing drugs, it is clear that a good understanding of the hetero-Michael addition reaction and the relative reactivities of biological thiols with Michael acceptors under physiological conditions is needed for the design and use of these compounds as biological tools and potential therapeutics. This perspective provides information that will contribute to this understanding, such as kinetics of thiol addition reactions, bioactivities, as well as steric and electronic factors that influence the electrophilicity and reversibility of Michael acceptors. This perspective is focused on α,β-unsaturated carbonyls given their preponderance in bioactive natural products.

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NF-κB DNA binding activity of sesquiterpene lactones fromAnthemis arvensisandAnthemis cotula

Cited by 4 publications

References 13 publications

The Study of the Composition of the Extract and Antimycotic Properties Anthemis Altissima L.

The Study of the Composition of the Extract and Antimycotic Properties Anthemis Altissima L.

Antioxidant activities of eight Algerian plant extracts and two essential oils

Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions

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