Nexus between extracellular vesicles, immunomodulation and tissue remodeling: for good or for bad?

Fatima, Farah; Nawaz, Muhammad

doi:10.21037/atm.2017.03.71

Cited by 11 publications

(19 citation statements)

References 27 publications

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“…This will help to put experimental guidelines into practice. Since there is intensive interest in the field both in basic research as well as therapeutic point of view, it is anticipated that in the next decade, EVs arena will see significant advances in clinical pipelines [32].…”

Section: Resultsmentioning

confidence: 99%

“…EVs derived from antigen presenting cells or cancer cells may also have a profound effect on immunomodulation, including both immune suppression and immune activation [30,32,33]. There is emerging role of EVs implicated in cellular differentiation, stem cell maintenance, and defining cell fates by facilitating the transmission of biological information from donor cells to recipient cells (reviewed elsewhere [22]).…”

Section: Biological Functions Of Extracellular Vesiclesmentioning

confidence: 99%

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Mining Extracellular Vesicles for Clinically Relevant Noninvasive Diagnostic Biomarkers in Cancer

Nawaz¹,

Fatima²,

Squire³

2017

Novel Implications of Exosomes in Diagnosis and Treatment of Cancer and Infectious Diseases

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Extracellular vesicles (EVs) are nanosized vesicles secreted by virtually all cell types into the extracellular milieu. EVs transport bioactive molecules between cells and play multifaceted roles in cell-to-cell communications and in the pathogenesis of various human diseases including cancer. EVs are currently a focus of intensive interest, mainly because they hold a wealth of biological information in the form of differentially expressed nucleic acids and proteins, including DNA and cancer-related mutated genes, microRNAs, and a variety of transcriptional factors. Both the mutational content and any differentially expressed RNA are highly stable in patient blood or urine because they are encapsulated in EVs. This protects them against nuclease activity, pH change, temperature fluctuations, and multiple free-thaw cycles. Therefore, EVs isolated from patient fluids may serve as an ideal source of liquid biopsy for mining cancer signatures through mutation screening and genetic profiling. However, the methods for obtaining pure and intact EVs from patient samples, as well as the optimized characterization of tumor-derived EVs are still not rigorously defined for routine clinical use. High-throughput genomic or proteomic platforms may aid in the identification of novel diagnostic and prognostic biomarkers that collectively could lead to cancer monitoring and improved patient outcome.

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Section: Resultsmentioning

confidence: 99%

Section: Biological Functions Of Extracellular Vesiclesmentioning

confidence: 99%

Mining Extracellular Vesicles for Clinically Relevant Noninvasive Diagnostic Biomarkers in Cancer

Nawaz¹,

Fatima²,

Squire³

2017

Novel Implications of Exosomes in Diagnosis and Treatment of Cancer and Infectious Diseases

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“…It has been reviewed that EVs secreted from these stem cell sources potentially mimic the features of their secreting stem cell and are widely recognized as evolving factors in stem cell biology (12). The most frequently reported are the MSCs-derived EVs with potential therapeutic effects in tissue regeneration and organ healing (24)(25)(26)(27)(28)(29).…”

Section: Introductionmentioning

confidence: 99%

“…Although, much has been documented about their participation in repair processes (29); less is known about how stem cell-derived EVs (from both normal stem cells and CSCs) contribute in cancer progression and mediate resistance to therapies. This review will, therefore, provide a detailed summary of recent developments of stem cell secreted EVs in tumor progression as well as tumor inhibition with mechanistic insights into stem cells, EVs, ncRNAs and intratumoral networking.…”

Section: Introductionmentioning

confidence: 99%

Extracellular vesicle-mediated transport of non-coding RNAs between stem cells and cancer cells: implications in tumor progression and therapeutic resistance

Nawaz

2017

Stem Cell Investig.

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Recent years have witnessed intensive progress in studying extracellular vesicles (EVs), both for understanding their basic biology and contribution to variety of diseases, biomarker discovery, and their potential as gene delivery vectors and source of innovative therapies. As such, stem cell-derived EVs have contributed significant knowledge which led to the development of cell-free therapies in regenerative medicine. Although, the role of stem cell-derived EVs in maintaining stemness, differentiation and repairing tissue injuries is relatively well-understood; however, knowledge about the contribution of stem cell-derived EVs in cancer progression is just emerging. The aim of this review is, therefore, to discuss the recent developments in stem cell-derived EVs and tumor progression, placing a particular focus on non-coding RNA (ncRNA) mediated cancer progression and resistance against therapies. This includes the failure of normal hematopoiesis and the progression of myeloid neoplasms, enhanced capacity of cancer cells to proliferate and metastasize, and the conversion of normal cells into cancer cells, activation of angiogenic pathways and dormancy in cancer cells. These processes are shared by mesenchymal stem cells (MSCs), cancer stem like-cells and cancer cells in an intricate intratumoral network in order to create self-strengthening tumor niche. In this context, EV-ncRNAs serve as mediators to relay bystander effects of secreting cancer stem cells (CSCs) into recipient cells for priming a tumor permissive environment and relaying therapeutic resistance. Collectively, this knowledge will improve our understandings and approaches in finding new therapeutic targets in the context of CSCs, which could be benefited through engineering EVs for innovative therapies.

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“…It is expected that new advances in technologies and optimized protocols for the isolation and characterization will certainly foster progress in obtaining pure vesicles. This will greatly influence the identification of specific biomarkers when intended from various diseases as well as therapeutic utility of EVs [120,163].…”

Section: Characterization Of Extracellular Vesiclesmentioning

confidence: 99%

Estudo sobre as respostas inflamatórias em modelo experimental de artrite séptica induzida por Staphylococcus aureus e suas vesículas

Fatima¹

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I would like to express my profound gratitude to all those who helped me in different ways during my PhD. In particular I am rather indebted to thank; Luciano Neder: PhD supervisor, for giving me the opportunity to work in his group. His kind supervision, guidance, and allowing me to work at my own pace and comfort made this submission possible. The biggest appreciation is the opportunity he gave me to have a work-life balance, allowing me to take decision that are suitable for my scenarios that allowed me complete mental strength and peace to fulfil my work efficiently. I will ever be thankful for all this. Tao Jin: my co-supervisor, who proved to be one of the productive additions in my scientific career. It was a great experience being at Gothenburg and exploring new areas of research in his lab at Sahlgrenska Academy. He provided me with great lab facilities along with complete independence and confidence to work independently on new projects. His friendly way of mentoring will always leave a mark on my future research career. Alfredo Ribeiro da Silva and other members of the postgraduate program of department of pathology: for making things easy going, documentations and related matters at the department. Many thanks to my lab colleagues both in Brazil and Sweden; Bruna Zanetti, Niele Dias Mendes, Renata Silvestre, Nathalia and Isabela, Deise, Anabelle, Abukar, Manli, Fei and Majd for their pleasant company and assistance during my research work as well as facilitating my stay in the lab. Camila Zambonini: Thank you so much for administrative help during all my time at this department. It was all hard to complete PhD. I also thank Felipe Denipotte Coelho, Rodrigo Banzi, Rosangela, Neide Terezinha and Antonio de Padua for helping me in several ways. Yes, that IT expert guy: every time appears with a whistle and solves the technical issues. Finally, my deepest gratitude goes to my parents for unconditional love and support throughout my life. Their hard work and dedication made me able to achieve what I seek today. Unfortunately they left too soon to see that there efforts no doubt made me stand where I am today. Their uncountable prayers have, and will always lighten my paths. May they rest in the highest place of Jannah (Heaven). Ameen. Muhammad Umer, my only brother, my first friend and my mentor and role model in every aspect of life. The space you left can never be filled. My sisters Nadia Haroon, Aisha Jaudat and Madiha Aslam for the continous support, friendly chats and unconditional love, my brother in laws Haroon Jamil, Jaudat Fayyazi and Shehzad Aslam for their prayers, wishes and support and my little group of loud and fun gang, my nephews Abdur rehman Haroon, Rayyan Aslam, Fahad Haroon and Muhammad Azlan and our lovely princess Aidha Jaudat for the fun times, treats and lovely bonding. Moreover, I extend special thanks to my in-laws for their continuous prayers and wishes for my success in life. May Allah keep my whole family and relatives, healthy and place them among His loved ones. Ameen Last bu...

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Nexus between extracellular vesicles, immunomodulation and tissue remodeling: for good or for bad?

Cited by 11 publications

References 27 publications

Mining Extracellular Vesicles for Clinically Relevant Noninvasive Diagnostic Biomarkers in Cancer

Mining Extracellular Vesicles for Clinically Relevant Noninvasive Diagnostic Biomarkers in Cancer

Extracellular vesicle-mediated transport of non-coding RNAs between stem cells and cancer cells: implications in tumor progression and therapeutic resistance

Estudo sobre as respostas inflamatórias em modelo experimental de artrite séptica induzida por Staphylococcus aureus e suas vesículas

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