Next‐generation sequencing reveals remarkable genetic stability in primary and corresponding recurrent intestinal‐type sinonasal adenocarcinoma
Cristina Riobello,
Paula Sánchez‐Fernández,
María Camila Cubides Córdoba
et al.
Abstract:BackgroundRecurrent intestinal‐type sinonasal adenocarcinoma (ITAC) can occur several years after primary treatment and with different histology. We aimed to clarify if such recurrences could be second primary tumors and to identify actionable mutations as targets for personalized treatment of recurrent ITAC.MethodsTwelve pairs of primary and recurrent ITAC were histologically examined and analyzed by next‐generation sequencing.ResultsHistological differences between primary and recurrent tumor pairs were obse… Show more
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