Next-generation sequencing of the monogenic obesity genes LEP , LEPR , MC4R , PCSK1 and POMC in a Norwegian cohort of patients with morbid obesity and normal weight controls

Nordang, Gry B. N.; Busk, Øyvind L.; Tveten, Kristian; Hanevik, Hans Ivar; Fell, Anne Kristin Møller; Hjelmesæth, Jøran; Holla, Øystein L.; Hertel, Jens Kristoffer

doi:10.1016/j.ymgme.2017.03.007

Cited by 53 publications

(53 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…14 The mutation is very rare and reported in only 7 of 123,034 individuals in the Genome Aggregation Database (gnomAD), where 6 of these are of European origin and the last carrier is East Asian. 15 The variant has previously been reported in relation to extreme and early onset obesity, mostly in Europeans, 2,4,12,16 but also in Pima Indians. 17 Anthropometrics and Blood Analyses Before and After Liraglutide Treatment During 16 weeks of liraglutide treatment, the patient lost a total of 9.7 kg (from 152.2 kg to 142.5 kg).…”

Section: Genetic Characteristicsmentioning

confidence: 93%

GLP-1 Receptor Agonist Treatment in Morbid Obesity and Type 2 Diabetes Due to Pathogenic Homozygous Melanocortin-4 Receptor Mutation: A Case Report

Iepsen

Have

Veedfald

et al. 2020

Cell Reports Medicine

View full text Add to dashboard Cite

show abstract

Section: Genetic Characteristicsmentioning

confidence: 93%

GLP-1 Receptor Agonist Treatment in Morbid Obesity and Type 2 Diabetes Due to Pathogenic Homozygous Melanocortin-4 Receptor Mutation: A Case Report

Iepsen

Have

Veedfald

et al. 2020

Cell Reports Medicine

View full text Add to dashboard Cite

show abstract

“…This means that disease causative alleles are likely to be enriched or become specific to few ethnic groups, increasing their risk towards the disease. Other factors like economic background, diet, psychological stress and accessible medical care also influence the development of obesity ( Jiao et al, 2015 , McPherson et al, 2014 , Nielsen et al, 2015 , Nordang et al, 2017 ).…”

Section: Geneticsmentioning

confidence: 99%

Impact of weight loss predictors in severe-morbid obesity patients in the Saudi population

Al-Nbaheen

2020

Saudi Journal of Biological Sciences

View full text Add to dashboard Cite

Universally, obesity has been affected more than 650 million and converts as global health problem. Obesity is equally affecting starting from children to elder population. Obese subjects are converting into severe obese and then into morbid obesity. Body mass index is proning from 30 to 50 kg/m 2 in the adult population. Obesity is connected with the future complications of hypertension, type 2 diabetes mellitus, cardiovascular, stroke, osteoarthritis, obstructive sleep apnea and liver diseases. Loosing of body fat is the only option to avoid obesity and this could be achieved with routine physical activity and diet modifications. Obesity subjects may fail to achieve the daily routine activities or insufficient activity may be involved and finally fail to lose the body fat after the medical course. Then these severe or morbidity obese can be lose with the existing surgery. Currently, Bariatric Surgery (BS) has become the active treatment for long-term weight loss. Various types (Roux-en-Y gastric bypass, sleeve gastrectomy and duodenal switch and the jejunoileal bypass) of BS are performed on the gastrointestinal tract. Throughout the world population, BS has found to be safe in losing the weight and avoiding the future and long-term complications. The prevalence of overweight and obesity in Saudi Arabia is an issue in terms of incidence and health consequences. Maximum obesity studies involved in Saudi Arabia has proven to be develop the long-term complications in the future involving from child to morbid obesity. Limited bariatric studies carried out in the Saudi subjects confirmed as effective tool in lowering the body fat and avoiding the life-threatened complications of human diseases. So, this review recommends BS as effective and safe surgical treatment to lose body fat in the Saudi population. However, post-operative monitoring is mandatory to follow-up.

show abstract

“…PCSK1 has a crucial importance on the appetite and metabolism regulation, as the protein (PC1/3) coded by PCSK1 converts the proteins of proinsulin and proglucagon to their active biological forms (Rouillé et al, 1997). Genetic variations in PCSK1 have been associated, although heavily debated, with sensitivity to obesity and in particular childhood obesity, severe obesity and race (Choquet & Meyre, 2011;Choquet et al, 2013;Kulanuwat et al, 2014;Dušátková et al, 2015;Kulanuwat et al, 2015;Nordang et al, 2017). In relation to AIWG, the presence of a catecholamine like dopamine or antipsychotics like haloperidol has shown to influence the levels of PC1/3 and could point towards a possible connection with AIWG not yet discovered (Day et al, 1992;Oyarce et al, 1996;Helwig et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Molecular pathway analysis associates alterations in obesity-related genes and antipsychotic-induced weight gain

Corfitsen

Krantz

Drago

2019

Acta Neuropsychiatr.

View full text Add to dashboard Cite

Objective:Antipsychotics often induce excessive weight gain. We hypothesised that individuals with genetic variations related to known obesity-risk genes have an increased risk of excessive antipsychotic-induced weight gain (AIWG). This hypothesis was tested in a subset of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) trial data set.Methods:The CATIE trial compared effects and side effects of five different antipsychotics through an 18-month period. Based on the maximum weight gain recorded, excessive weight gain was defined as >7% weight gain. Cytoscape and GeneMANIA were instrumental in composing a molecular pathway from eight selected genes linked to obesity. Genetic information on a total of 495.172 single-nucleotide polymorphisms (SNPs) were available from 765 (556 males) individuals. Enrichment test was conducted through ReactomePA and Bioconductor. A permutation test was performed, testing the generated pathway against 105 permutated pathways (p ≤ 0.05). In addition, a standard genome-wide association study (GWAS) analysis was performed.Result:GWAS analysis did not detect significant differences related to excessive weight gain. The pathway generated contained 28 genes. A total of 2067 SNPs were significantly expressed (p < 0.01) within this pathway when comparing excessive weight gainers to the rest of the sample. Affected genes including PPARG and PCSK1 were not previously related to treatment-induced weight gain.Conclusions:The molecular pathway composed from high-risk obesity genes was shown to overlap with genetics of patients who gained >7% weight gain during the CATIE trial. This suggests that genes related to obesity compose a pathway of increased risk of excessive AIWG. Further independent analyses are warranted that may confirm or clarify the possible reasoning behind.

show abstract

Next-generation sequencing of the monogenic obesity genes LEP , LEPR , MC4R , PCSK1 and POMC in a Norwegian cohort of patients with morbid obesity and normal weight controls

Cited by 53 publications

References 57 publications

GLP-1 Receptor Agonist Treatment in Morbid Obesity and Type 2 Diabetes Due to Pathogenic Homozygous Melanocortin-4 Receptor Mutation: A Case Report

GLP-1 Receptor Agonist Treatment in Morbid Obesity and Type 2 Diabetes Due to Pathogenic Homozygous Melanocortin-4 Receptor Mutation: A Case Report

Impact of weight loss predictors in severe-morbid obesity patients in the Saudi population

Molecular pathway analysis associates alterations in obesity-related genes and antipsychotic-induced weight gain

Contact Info

Product

Resources

About