Next-generation sequencing identifies articular cartilage and subchondral bone miRNAs after ESWT on early osteoarthritis knee

Cheng, Jai-Hong; Wang, Ching‐Jen; Su, Shi-Hao; Huang, Chien-Yiu; Hsu, Shan-Ling

doi:10.18632/oncotarget.11331

Cited by 10 publications

(11 citation statements)

References 47 publications

(50 reference statements)

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“…As a new technique, extracorporeal shockwave therapy (ESWT) uses a single-impulse transient acoustic wave induced by pneumatic, electrohydraulic, electromagnetic, or piezoelectric generators which focuse on the area needed to be treated [7]. ESWT has shown an effect on articular cartilage and subchondral bone development, neovascularization, tissue regeneration, and inflammatory response in some animal experiments [8][9][10]. ESWT also succeeds in the treatment of several musculoskeletal diseases, including tennis elbow syndrome, plantar fasciitis, tendon disease, and fracture nonunions, in some clinical studies [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Extracorporeal Shock Wave Therapy for the Treatment of Osteoarthritis: A Systematic Review and Meta-Analysis

Chen

Liu

et al. 2020

BioMed Research International

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Background. Osteoarthritis is the most common musculoskeletal disease. Extracorporeal shockwave therapy had shown an effect on osteoarthritis in both some animal experiments and clinical studies, but there was no systematic review to confirm the value of shockwave therapy in the treatment of all types of osteoarthritis and compare it with other traditional therapies (especially traditional Chinese medicine). Method. PubMed, Medline, the Cochrane Central Register of Controlled Trials, Web of Science, Chinese National Knowledge Infrastructure, WANFANG database, and VIP database were searched up to December 10, 2019, to identify randomized controlled trials comparing shockwave therapy and other treatments for osteoarthritis. Visual analogue scale and the Western Ontario and McMaster Universities Osteoarthritis Index were extracted and analyzed by RevMan and STATA software as outcomes of pain reduction and functional improvement. Adverse reactions were recorded to evaluate the safety of shockwave therapy. Results. Shockwave therapy had significant improvement in both pain reduction and functional improvement compared with placebo, corticosteroid, hyaluronic acid, medication, and ultrasound (P < 0:05). In functional improvement, shockwave therapy showed statistical improvement compared with kinesiotherapy and moxibustion (P < 0:05) but not with acupotomy surgery (P = 0:24). A significant difference between shockwave therapy and platelet-rich plasma was observed in pain reduction (P < 0:05) but not in functional improvement (P = 0:89). Meanwhile, a statistical difference was found between shockwave therapy and fumigation in functional improvement (P < 0:05) but not in pain reduction (P = 0:26). Additionally, there was no statistically significant difference between shockwave therapy and manipulation in both pain reduction (P = 0:21) and functional improvement (P = 0:45). No serious adverse reaction occurred in all of studies. Conclusions. Extracorporeal shockwave therapy could be recommended in the treatment of osteoarthritis as a noninvasive therapy with safety and effectiveness, but the grade of recommendations needs to be discussed in a further study.

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Section: Introductionmentioning

confidence: 99%

Extracorporeal Shock Wave Therapy for the Treatment of Osteoarthritis: A Systematic Review and Meta-Analysis

Chen

Liu

et al. 2020

BioMed Research International

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“…Cheng et al [15] performed a gene analysis of miRNAs expressed in joint tissues after an application of ESWT, revealing rather conflicting data that do not allow us to reach clear and definitive conclusions regarding the role of ESWT in EKOA.…”

Section: Discussionmentioning

confidence: 99%

“…The chondroprotective role of ESWT was also evaluated by Cheng et al [15], who performed a gene processing of microRNAs (miRs) found in articular cartilage and subchondral bone following ESWT. The authors conducted a preclinical study on 30 rats undergoing ACL resection in combination with MMx (ACLT + MMx) to induce EOA-like changes in joints (OA group).…”

Section: Eswtmentioning

confidence: 99%

Physical Agent Modalities in Early Osteoarthritis: A Scoping Review

et al. 2021

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Early osteoarthritis (EOA) still represents a challenge for clinicians. Although there is no consensus on its definition and diagnosis, a prompt therapeutic intervention in the early stages can have a significant impact on function and quality of life. Exercise remains a core treatment for EOA; however, several physical modalities are commonly used in this population. The purpose of this paper is to investigate the role of physical agents in the treatment of EOA. A technical expert panel (TEP) of 8 medical specialists with expertise in physical agent modalities and musculoskeletal conditions performed the review following the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) model. The TEP searched for evidence of the following physical modalities in the management of EOA: “Electric Stimulation Therapy”, “Pulsed Electromagnetic field”, “Low-Level Light Therapy”, “Laser Therapy”, “Magnetic Field Therapy”, “Extracorporeal Shockwave Therapy”, “Hyperthermia, Induced”, “Cryotherapy”, “Vibration therapy”, “Whole Body Vibration”, “Physical Therapy Modalities”. We found preclinical and clinical data on transcutaneous electrical nerve stimulation (TENS), extracorporeal shockwave therapy (ESWT), low-intensity pulsed ultrasound (LIPUS), pulsed electromagnetic fields stimulation (PEMF), and whole-body vibration (WBV) for the treatment of knee EOA. We found two clinical studies about TENS and PEMF and six preclinical studies—three about ESWT, one about WBV, one about PEMF, and one about LIPUS. The preclinical studies demonstrated several biological effects on EOA of physical modalities, suggesting potential disease-modifying effects. However, this role should be better investigated in further clinical studies, considering the limited data on the use of these interventions for EOA patients.

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“…11 ESWT creates a micro-trauma which induces angiogenesis, [12][13][14][15][16] potentially reducing inflammation and improving the quality of cartilage. 9,[17][18][19][20] It decreases nerve conduction velocity, which could explain the immediate antinociceptive effect. [21][22][23][24] However, the exact mechanism of action on the pain is still uncertain.…”

Section: Introductionmentioning

confidence: 99%

Terapia de ondas de choque focal para osteoartrose de joelho: um ensaio clínico randomizado duplo-cego

et al. 2017

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Objective: To assess the efficacy of focused extracorporeal shockwave therapy (f-ESWT) when compared to sham for pain and disability in patients with knee osteoarthritis (OA). Methods: Randomized, parallel, double-blind, sham-controlled clinical trial. Patients with primary knee OA were given a set of exercises (hamstring stretching and quadriceps strengthening) and randomized into f-ESWT or sham (sham probe). All patients were submitted to 4 weekly sessions of 7,000 pulses, and in the f-ESWT group energy was up to 0.15mJ/mm2. Primary outcome was visual analog scale (VAS) for pain at 1 month. Secondary outcomes were WOMAC, TUG, Lequesne's index and OMERACT-OARSI responder index at 1 and 3 months; as well as VAS at 3 months and adverse events (AEs). Both patients and outcome assessors were blinded. Mann-Whitney U test and Fisher's exact test were used with alpha=5% and power=80% in an intention-to-treat analysis. Continuous outcomes were reported as mean± standard deviation. Results: 18 patients were included (9 in each group), aging 60.6±8.7, with 33.3% males. There was no significant difference at baseline across groups in any variables. Active f-ESWT was not superior to sham f-ESWT at 1 month: VAS=-2.97±3.18 and-2.68±2.33cm, respectively, p=0.96. TUG at 1 month had significant differences: 9.09±2.30 and 11.01±2.85sec, p=0.01. No serious AEs were observed. Conclusions: Active f-ESWT was not superior to sham f-ESWT for knee OA. This RCT was underpowered to detect differences in this study. New RCTs should use WOMAC A (pain subscale) as primary outcome and recruit at least 92 patients.

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Next-generation sequencing identifies articular cartilage and subchondral bone miRNAs after ESWT on early osteoarthritis knee

Cited by 10 publications

References 47 publications

Extracorporeal Shock Wave Therapy for the Treatment of Osteoarthritis: A Systematic Review and Meta-Analysis

Extracorporeal Shock Wave Therapy for the Treatment of Osteoarthritis: A Systematic Review and Meta-Analysis

Physical Agent Modalities in Early Osteoarthritis: A Scoping Review

Terapia de ondas de choque focal para osteoartrose de joelho: um ensaio clínico randomizado duplo-cego

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