Next generation sequencing for biliary tract cancers

DiPeri, Timothy P.; Javle, Milind; Meric‐Bernstam, Funda

doi:10.1080/17474124.2021.1896967

Cited by 13 publications

(6 citation statements)

References 25 publications

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“…58 ). A relatively recent review from 2021 describes a number of clinical studies underway 59 . Kushnir et al, showed that whether it is a combination of the FISH method or PCR-based mutation profiling (commercially available as PancraGEN, Interpace Diagnostics) with cytology, both combinations clearly lead to a higher detection of malignant lesions compared to cytology alone (44% and 56% vs. 26%) (ref.…”

Section: Next Generation Sequencingmentioning

confidence: 99%

The contribution of new methods in cytology for increasing sensitivity in the diagnosis of extrahepatic bile duct lesions

Kurfurstova,

Slobodova,

Zoundjiekpon

et al. 2023

BIOMED PAP

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The aim of this review is to provide a comprehensive analysis of the existing literature pertaining to cytology of extrahepatic bile ducts. A search using the keywords "biliary brush cytology" was conducted in the PubMed database, with a focus on recent articles. The inclusion criteria primarily encompassed publications addressing problematic biliary stenosis. Emphasis was placed on identifying articles that explored innovative or less-utilized examination techniques aimed at enhancing the sensitivity of cytological examination. This review presents a comprehensive overview of the various types of materials used in sampling and the corresponding sampling methods. Additionally, it explores cytological and cytogenetic techniques, such as fluorescence in situ hybridization (FISH) and genetic methods (miRNA, NGS, cfDNA). These techniques possess the potential to improve the accuracy of diagnosing bile duct tumors, although their sensitivity varies. Furthermore, their utilization can facilitate early therapy, which plays a crucial role in patient prognosis. Each examination is always dependent on the quality and quantity of material delivered. A higher sensitivity of these examinations can be achieved by combining biliary cytology and other complementary methods.

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Section: Next Generation Sequencingmentioning

confidence: 99%

The contribution of new methods in cytology for increasing sensitivity in the diagnosis of extrahepatic bile duct lesions

Kurfurstova,

Slobodova,

Zoundjiekpon

et al. 2023

BIOMED PAP

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“…With the advent of NGS, the identification of recurrent genomic alterations in cholangiocarcinoma was made possible opening the door for biomarker-selected clinical trials. 1…”

Section: Advances In Treatmentmentioning

confidence: 99%

Advances in the diagnosis and treatment of cholangiocarcinoma over the past decade

Lee

2023

Int J Gastrointest Interv

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“…Существует общая тенденция к мультимодальному лечению, перспективы которой связывают с ожиданиями лучшего эффекта от системной лекарственной терапии [33][34][35]. Одним из перспективных направлений повышения эффективности лекарственной терапии является использование высокопроизводительного секвенирования нового поколения NGS (next generation sequencing), которое позволяет расширить представления о патогенезе внутрипеченочной холангиокарциномы и обнаружить перспективные молекулярные мишени для таргетной терапии [36,37].…”

Section: роль локорегионарных методов лечения при нерезектабельных ре...unclassified

Surgical treatment of recurrent intrahepatic cholangiocarcinoma (systematic review)

Britskaya,

Fisenko,

Efanov

2023

Malignant Tumours

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Background: Liver resection for intrahepatic cholangiocarcinoma is accompanied by a high recurrence rate (up to 70 %) in the first 2 years after surgery. The results of treatment of recurrent intrahepatic cholangiocarcinoma are evaluated inconsistently.Aim: The results of repeated liver resections and methods of locoregional therapy for reccurent intrahepatic cholangiocarcinoma were analysed based on literature data.Materials and methods: Two publication databases have been used for search: PubMed and Google Scholar. Finally, 35 papers published from 2010 to 2022 were included in review.Results: Repeated liver resections followed by chemotherapy provide better long-term results compared to other methods of local therapy and systemic drug treatment. The rate of perioperative morbidity does not differ from resections for primary tumors. Repeat liver resection is possible in a limited number of patients (8–10 %). Thorough selection of patients is necessary in terms of prognosis and biological behavior of the tumor.Conclusion: Evidence for the benefit of resections in the treatment of recurrent intrahepatic cholangiocarcinoma is based on a scarse number of studies analyzing relatively small and heterogeneous patient cohorts. Patient selection is needed, the criteria for which are still being discussed.

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Next generation sequencing for biliary tract cancers

Cited by 13 publications

References 25 publications

The contribution of new methods in cytology for increasing sensitivity in the diagnosis of extrahepatic bile duct lesions

The contribution of new methods in cytology for increasing sensitivity in the diagnosis of extrahepatic bile duct lesions

Advances in the diagnosis and treatment of cholangiocarcinoma over the past decade

Surgical treatment of recurrent intrahepatic cholangiocarcinoma (systematic review)

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