Next-Generation Proteasome Inhibitor Oprozomib Synergizes with Modulators of the Unfolded Protein Response to Suppress Hepatocellular Carcinoma

Vandewynckel, Yves-Paul; Coucke, Céline; Laukens, Debby; Devisscher, Lindsey; Paridaens, Annelies; Bogaerts, Eliene; Vandierendonck, Astrid; Raevens, Sarah; Verhelst, Xavier; Steenkiste, Christophe Van; Libbrecht, Louis; Geerts, A.; Vlierberghe, Hans Van

doi:10.1016/s0168-8278(16)01069-2

Cited by 1 publication

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References 21 publications

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“…Therefore, while ER stress is necessary for the cancer progression and spread, the utility of ER stress inhibitors as anti-cancer drugs in the clinics will require careful consideration and critical evaluation of benefits and drawbacks. One possibility for treatment would be to combine UPR inhibitors with those targeting the proteasome as shown recently in case of models of hepatocellular carcinoma (Vandewynckel et al, 2016). …”

Section: Upr and Er Stress In Cancermentioning

confidence: 99%

Recent Insights into the Role of Unfolded Protein Response in ER Stress in Health and Disease

Lindholm

Korhonen

Eriksson

et al. 2017

Front. Cell Dev. Biol.

171

139

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Unfolded stress response (UPR) is a conserved cellular pathway involved in protein quality control to maintain homeostasis under different conditions and disease states characterized by cell stress. Although three general schemes of and genes induced by UPR are rather well-established, open questions remain including the precise role of UPR in human diseases and the interactions between different sensor systems during cell stress signaling. Particularly, the issue how the normally adaptive and pro-survival UPR pathway turns into a deleterious process causing sustained endoplasmic reticulum (ER) stress and cell death requires more studies. UPR is also named a friend with multiple personalities that we need to understand better to fully recognize its role in normal physiology and in disease pathology. UPR interacts with other organelles including mitochondria, and with cell stress signals and degradation pathways such as autophagy and the ubiquitin proteasome system. Here we review current concepts and mechanisms of UPR as studied in different cells and model systems and highlight the relevance of UPR and related stress signals in various human diseases.

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Section: Upr and Er Stress In Cancermentioning

confidence: 99%