Next-generation Multidimensional NMR Spectrometer Based on Semiconductor Technology

Ha, Dongwan; Sun, Nan; Ham, Donhee

doi:10.1002/9780470034590.emrstm1421

Cited by 5 publications

(7 citation statements)

References 20 publications

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“…Commercial tabletop NMR instruments employ compact transmit-receive electronics (Blümich et al, 2014;Blümich, 2016;Blümich and Singh, 2018), which, although reliable, are nevertheless too large and power-hungry for mobile use. Their state of the art has been surpassed by the development of smaller, single-chip-based magnetic resonance transceivers (Zalesskiy et al, 2014;Ha et al, 2014Ha et al, , 2015Grisi et al, 2015;Chu et al, 2017;Anders et al, 2017). In particular, a small monolithic spectrometer has been developed (Bürkle et al, 2020), which uses a high-voltage CMOS processer with supply voltages up to 25 V for enhanced driving strength to combine the monolithic NMR-on-a-chip approach with macroscopic, centimeter-sized coils.…”

Section: The All-in-one Instrumentmentioning

confidence: 99%

When the MOUSE leaves the house

Blümich

Anders

2021

Magn. Reson.

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Abstract. Change is inherent to time being transient. With the NMR-MOUSE (MObile Universal Surface Explorer) having matured into an established NMR tool for nondestructive testing of materials, this forward-looking retrospective assesses the challenges the NMR-MOUSE faced when deployed outside a protected laboratory and how its performance quality can be maintained and improved when operated under adverse conditions in foreign environments. This work is dedicated to my dear colleague and friend Geoffrey Bodenhausen on the occasion of his crossing an honorable timeline in appreciation of his ever-continuing success of fueling the dynamics of magnetic resonance.

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Section: The All-in-one Instrumentmentioning

confidence: 99%

When the MOUSE leaves the house

Blümich

Anders

2021

Magn. Reson.

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“…Commercial tabletop NMR instruments employ compact transmit-receive electronics (Blümich et al, 2014;Blümich, 2016;Blümich and Singh, 2018), which, although reliable, nevertheless, are too large and power-hungry for mobile use. Their state-of-the-art has been surpassed by the development of smaller, single-chip based magnetic resonance transceivers (Zalesskiy et al, 2014;Ha et al, 2014;Ha et al, 2015;Grisi et al, 2015;Chu et al, 2017;Anders et al, 2017). In particular, a small monolithic spectrometer has been developed (Bürkle et al, 2020), which uses a high-voltage CMOS process with supply voltages up to 25 V for enhanced driving strength to combine the monolithic NMR-on-a-chip approach with macroscopic, cm-sized coils.…”

Section: The All-in-one Instrumentmentioning

confidence: 99%

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Bluemich

2021

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Change is inherent to time being transient. With the NMR-MOUSE having matured into an established NMR tool for nondestructive testing of materials, this forward-looking retrospective assesses the challenges the NMR-MOUSE faced when deployed outside a protected laboratory and how it's performance quality can be maintained and improved when operated under adverse conditions in foreign environments. This work is dedicated to my dear colleague and friend Geoffrey Bodenhausen on the occasion of his crossing an honorable timeline in appreciation of his ever-continuing success of fueling the dynamics of magnetic resonance. IntroductionThe MOUSE (MObile Universal Surface Explorer) (Eidmann et al., 1996) is a portable stray-field NMR sensor suited for non-destructive testing of materials (Blümich et al., 2008;Casanova et al., 2011) With it the relaxation of nuclear spins towards equilibrium is measured following perturbation by radio-frequency pulses. The sensor is a small and compact NMR relaxometer that investigates an object from one side and can be carried along to the site of interest. As such the NMR-MOUSE and other stray field relaxometers are one modality of compact NMR.

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“…With mobile and compact instruments being available commercially today, the quest for miniaturization continues [15][16][17]. So far shrinking size has gone along with shrinking price, and this trend can be expected to continue as miniaturization progresses.…”

Section: Miniaturization and Conclusionmentioning

confidence: 99%

“…Despite intriguing alternatives such as optical detection [251,252], inductive detection remains the scheme most explored in the context of miniaturization [253][254][255], where tuning to the low resonance frequencies of NMR with permanent magnets is enabled with sacrificial inductances [219], which, when fitted with a high-quality factor, can significantly boost the detection sensitivity [256]. Last but not least, individual components of the spectrometer as well as the entire circuitry have been miniaturized to chip-size components [257,258] and already been demonstrated to work even for NMR spectroscopy with a compact magnet the size of a human fist [16,259].…”

Section: Miniaturization and Conclusionmentioning

confidence: 99%

“…1b, c) employ permanent magnets that only allow measuring relaxation and diffusion but not high-resolution spectra due to the inhomogeneity of the magnetic Once the technology to build permanent magnets with sub-ppm field homogeneity had been developed, this situation has changed considerably ( Fig. 2) [3], and the quest today is to develop NMR instruments as small and compact as a cell phone for high-volume markets to be cultivated in the materials testing and health sectors [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

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Mobile and Compact NMR

Blümich

2016

Modern Magnetic Resonance

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NMR with mobile and compact devices is experiencing considerable growth in recent years in particular since instruments have become available, which are capable not only of measuring NMR relaxation but also images and highresolution spectra. Based on permanent magnet technology, compact tabletop NMR instruments measure samples of materials and solutions positioned inside the magnet, while compact mobile instruments measure material properties of intact objects and samples nondestructively in the inhomogeneous stray field outside the magnet. Following a brief introduction to NMR with homogeneous and inhomogeneous magnetic fields and to the concepts of permanent center-and stray-field NMR magnets, the evolution of the technology over the past 10 years is reviewed and illustrated with selected applications. Relaxation and diffusion measurements find use in the analysis of foods, biological tissues, polymer materials, porous media, and objects of cultural heritage. Compact imaging

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Next-generation Multidimensional NMR Spectrometer Based on Semiconductor Technology

Cited by 5 publications

References 20 publications

When the MOUSE leaves the house

When the MOUSE leaves the house

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Mobile and Compact NMR

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