Abstract:<i>HLA-DQA1</i> and <i>-DQB1</i> genes have significant and potentially causal associations
with autoimmune type 1 diabetes (T1D). To
follow on the earlier analysis on high-risk HLA-DQ2.5 and DQ8.1, the current
analysis uncovers seven residues (αa1, α157, α196, β9, β30, β57, β70) that are resistant
to T1D among subjects with DQ4, 5, 6 and 7 resistant DQ haplotypes. These seven residues form 13 common motifs;
six motifs are significantly resistant, six motifs have modest or no
associat… Show more
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