Next‐generation Antimicrobial Peptides (AMPs) incorporated nanofibre wound dressings

Afshar, Ayda; Yuca, Esra; Wisdom, Cate; Alenezi, Hussain; Ahmed, Jubair; Tamerler, Candan; Edirisinghe, Mohan

doi:10.1002/mds3.10144

Cited by 14 publications

(8 citation statements)

References 79 publications

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“…PVA nanofibers loaded with cinnamaldehyde phytoconstituent were fabricated to tackle the irritant effect associated with cinnamaldehyde and also to boost its therapeutic efficacy for eradicating Candida biofilm by solving the problem of high volatility and low aqueous solubility . In a recent development, antimicrobial peptides (AMPs) were also fabricated as nanofibers using poly(ethylene oxide) for the purpose of wound healing …”

Section: Fabrication Of Nanofibersmentioning

confidence: 99%

Evolving Trends in Nanofibers for Topical Delivery of Therapeutics in Skin Disorders

Tomar,

Pandit,

Priya

et al. 2023

ACS Omega

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Nanotechnology has yielded nanostructure-based drug delivery approaches, among which nanofibers have been explored and researched for the potential topical delivery of therapeutics. Nanofibers are filaments or thread-like structures in the nanometer size range that are fabricated using various polymers, such as natural or synthetic polymers or their combination. The size or diameter of the nanofibers depends upon the polymers, the techniques of preparation, and the design specification. The four major processing techniques, phase separation, self-assembly, template synthesis, and electrospinning, are most commonly used for the fabrication of nanofibers. Nanofibers have a unique structure that needs a multimethod approach to study their morphology and characterization parameters. They are gaining attention as drug delivery carriers, and the substantially vast surface area of the skin makes it a potentially promising strategy for topical drug products for various skin disorders such as psoriasis, skin cancers, skin wounds, bacterial and fungal infections, etc. However, the large-scale production of nanofibers with desired properties remains challenging, as the widely used electrospinning processes have certain limitations, such as poor yield, use of high voltage, and difficulty in achieving in situ nanofiber deposition on various substrates. This review highlights the insights into fabrication strategies, applications, recent clinical trials, and patents of nanofibers for different skin disorders in detail. Additionally, it discusses case studies of its effective utilization in the treatment of various skin disorders for a better understanding for readers.

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Section: Fabrication Of Nanofibersmentioning

confidence: 99%

Evolving Trends in Nanofibers for Topical Delivery of Therapeutics in Skin Disorders

Tomar,

Pandit,

Priya

et al. 2023

ACS Omega

View full text Add to dashboard Cite

show abstract

“…Besides the fact that the selected nisin concentrations were comparable to the minimum inhibitory concentration of nisin for S. aureus (10 μg/mL), rapid compound diffusion throughout the agar plate could explain the lack of antibacterial activity. In another work [ 107 ], the authors estimated the antibacterial activity of polyethylene oxide (PEO) material that contained one of the following two AMPs: GH12-COOH-M2 (type 1 AMP) and AMP2 (type 2 AMP). For this purpose, different concentrations (3.5, 7, 10.5, 14, and 17,5% w / v ) of tested AMPs were added to PEO materials.…”

Section: Antimicrobial Biomaterialsmentioning

confidence: 99%

Wound Dressing Modifications for Accelerated Healing of Infected Wounds

Vivcharenko

Trzaskowska

Przekora

2023

IJMS

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Infections that occur during wound healing involve the most frequent complications in the field of wound care which not only inhibit the whole process but also lead to non-healing wound formation. The diversity of the skin microbiota and the wound microenvironment can favor the occurrence of skin infections, contributing to an increased level of morbidity and even mortality. As a consequence, immediate effective treatment is required to prevent such pathological conditions. Antimicrobial agents loaded into wound dressings have turned out to be a great option to reduce wound colonization and improve the healing process. In this review paper, the influence of bacterial infections on the wound-healing phases and promising modifications of dressing materials for accelerated healing of infected wounds are discussed. The review paper mainly focuses on the novel findings on the use of antibiotics, nanoparticles, cationic organic agents, and plant-derived natural compounds (essential oils and their components, polyphenols, and curcumin) to develop antimicrobial wound dressings. The review article was prepared on the basis of scientific contributions retrieved from the PubMed database (supported with Google Scholar searching) over the last 5 years.

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“…An effective drug delivery strategy must encompass the above features but go beyond them and be able to interact with complex cellular functions in new ways [ 93 , 109 ]. Moreover, it needs to be biodegradable, biocompatible, and comfortable for patients with minimal adverse effects both during and after drug administration [ 95 , 110 ].…”

Section: Drug Deliverymentioning

confidence: 99%

“…The best wound dressings should serve multiple purposes, including preventing acute or chronic infection, preserving a balanced environment for moisture and gas exchange, absorbing extrudates and blood from wounds, and stimulating cell migration and proliferation, which will aid in wound healing [ 109 , 110 , 112 , 114 , 122 , 123 , 124 , 125 ]. All these characteristics can simultaneously be present in nanofibre wound dressings.…”

Section: Drug Deliverymentioning

confidence: 99%

Iron-Based Magnetic Nanosystems for Diagnostic Imaging and Drug Delivery: Towards Transformative Biomedical Applications

et al. 2022

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The advancement of biomedicine in a socioeconomically sustainable manner while achieving efficient patient-care is imperative to the health and well-being of society. Magnetic systems consisting of iron based nanosized components have gained prominence among researchers in a multitude of biomedical applications. This review focuses on recent trends in the areas of diagnostic imaging and drug delivery that have benefited from iron-incorporated nanosystems, especially in cancer treatment, diagnosis and wound care applications. Discussion on imaging will emphasise on developments in MRI technology and hyperthermia based diagnosis, while advanced material synthesis and targeted, triggered transport will be the focus for drug delivery. Insights onto the challenges in transforming these technologies into day-to-day applications will also be explored with perceptions onto potential for patient-centred healthcare.

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Next‐generation Antimicrobial Peptides (AMPs) incorporated nanofibre wound dressings

Cited by 14 publications

References 79 publications

Evolving Trends in Nanofibers for Topical Delivery of Therapeutics in Skin Disorders

Evolving Trends in Nanofibers for Topical Delivery of Therapeutics in Skin Disorders

Wound Dressing Modifications for Accelerated Healing of Infected Wounds

Iron-Based Magnetic Nanosystems for Diagnostic Imaging and Drug Delivery: Towards Transformative Biomedical Applications

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