Newly Diagnosed Adult-Onset Still Disease in Pregnancy

Pan, Vivien L.; Haruyama, Atsuko Z.; Guberman, Cristiane; Kitridou, Rodanthi C.

doi:10.1097/00006250-200305001-00024

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2022

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“…In addition, cases of AOSD in which the onset occurs during the perinatal period are rare. A summary of reported cases of AOSD from 1971 onwards in which the onset occurred during the perinatal period is shown in Table (13,14,(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30). Of the 22 patients, including the present patient, 20 (90.9%) were treated with corticosteroids.…”

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confidence: 93%

Adult-onset Still's Disease during Pregnancy Treated with Tocilizumab

et al. 2022

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A 28-year-old woman exhibited a spiking fever, arthritis, and liver disfunction when she was 22 weeks pregnant. She was diagnosed with adult-onset Still's disease (AOSD). As her condition was resistant to corticosteroid therapy, tocilizumab (TCZ) was selected. The TCZ treatment was effective, and she delivered a healthy child while receiving TCZ treatment. Cases in which AOSD first arises during pregnancy are rare, and there have been no reports of TCZ treatment for AOSD being initiated during pregnancy. Although the safety of TCZ treatment during pregnancy has not been established, it may be effective against severe AOSD that develops during pregnancy.

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