Newly developed nano-biocomposite embedded hydrogel to enhance drug loading and modulated release of anti-inflammatory drug

Varghese, Sophia; Chaudhary, Jai Prakash; Thareja, Prachi; Ghoroi, Chinmay

doi:10.1080/10837450.2023.2193254

Cited by 3 publications

(3 citation statements)

References 38 publications

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“…Therefore, films with higher amounts of nanocomposite exhibit lower swelling ratios. Varghese et al have observed a similar reduction in swelling ratio and disruption of polymeric chains on the addition of the iron-based nano biocomposite to the alginate matrix …”

Section: Resultsmentioning

confidence: 74%

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Iron Nano Biocomposite-Infused Biopolymeric Films: A Multifunctional Approach for Robust Skin Repair

Kumawat,

Dave,

Varghese

et al. 2024

ACS Appl. Mater. Interfaces

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Sodium alginate (SA) biopolymeric films have various limitations such as poor mechanical properties, high vapor permeability, lack of antibacterial activity, excessive burst release, and weak cell adhesion. To overcome these limitations, a strategy involving the integration of nanofillers into an SA film matrix is explored. In this context, a cost-effective iron-containing carbon nano biocomposite (FeCNB) nanofiller is developed using a solvent-free technique. This nanocomposite is successfully incorporated into the alginate film matrix at varying concentrations (0.05, 0.1, and 0.15%) aimed at enhancing its physicochemical and biological properties for biomedical applications. Characterization through FESEM and BET analyses confirms the porous nature of the FeCNB. EDX shows the FeCNB's uniform distribution upon its integration into the film matrix, albeit without strong chemical interaction with SA. Instead, hydrogen bonding interactions become apparent in the FTIR spectra. By incorporating the FeCNB, the mechanical attributes of the films are improved and the water vapor permeability approaches the desired range (2000−2500 g/ m 2 day). The film's swelling ratio reduction contributes to a decrease in water permeability. The antibacterial activity and sustained release property of the FeCNB-incorporated film are established using tetracycline hydrochloride (TCl), a model drug. The drug release profile resembled Korsmeyer-Peppas's release pattern. In vitro assessments via the MTT assay and scratch assay on NIH-3T3 cells reveal that FeCNB has no adverse effects on the biocompatibility of alginate films. The cell proliferation and adhesion to the SA film are significantly enhanced after infusion of the FeCNB. The in vivo study performed on the rat model demonstrates improved wound healing by FeCNB-impregnated films. Based on the comprehensive findings, the proposed FeCNB-incorporated alginate films prove to be a promising candidate for robust skin repair.

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Section: Resultsmentioning

confidence: 74%

“…A higher drug release from the TCl film can be attributed to its inherent hydrophilicity. However, the drug release from the matrix of the modified films decreased due to the reduction in hydrophilicity and swelling ratio . This implies that reduced water ingress into the SA film matrix affects the drug release.…”

Section: Resultsmentioning

confidence: 99%

Iron Nano Biocomposite-Infused Biopolymeric Films: A Multifunctional Approach for Robust Skin Repair

Kumawat,

Dave,

Varghese

et al. 2024

ACS Appl. Mater. Interfaces

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“… 174 , 175 Iron-based nano-biocomposite impregnated alginate formulation and ferulic acid-derived lignin nanoparticle disintegrate at colon pH, which achieves the delivery of targeting colon. 176 , 177 Curcumin, decorated with a prussian blue analog can be released in inflammatory tissue (acidic environment), which promotes the polarization of M2 macrophages and the clearance of ROS. 178 A mesoporous polydopamine-derived nanomedicine loading polyacrylic acid releases Sulfasalazine at the inflammatory site of colon to scavenge excessive ROS.…”

Section: Ibd Treatments: Based On Experimentsmentioning

confidence: 99%

Research advancements and perspectives of inflammatory bowel disease: A comprehensive review

Bai,

Wang,

et al. 2024

Science Progress

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Inflammatory bowel disease (IBD) is a chronic inflammatory disease with increasing incidence, such as Crohn's disease and ulcerative colitis. The accurate etiology and pathogenesis of IBD remain unclear, and it is generally believed that it is related to genetic susceptibility, gut microbiota, environmental factors, immunological abnormalities, and potentially other factors. Currently, the mainstream therapeutic drugs are amino salicylic acid agents, corticosteroids, immunomodulators, and biological agents, but the remission rates do not surpass 30–60% of patients in a real-life setting. As a consequence, there are many studies focusing on emerging drugs and bioactive ingredients that have higher efficacy and long-term safety for achieving complete deep healing. This article begins with a review of the latest, systematic, and credible summaries of the pathogenesis of IBD. In addition, we provide a summary of the current treatments and drugs for IBD. Finally, we focus on the therapeutic effects of emerging drugs such as microRNAs and lncRNAs, nanoparticles-mediated drugs and natural products on IBD and their mechanisms of action.

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Emulgels: a promising topical drug delivery system for arthritis management and care

Sinha,

Garg,

Nagaich

et al. 2023

Pharmaceutical Development and Technology

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Newly developed nano-biocomposite embedded hydrogel to enhance drug loading and modulated release of anti-inflammatory drug

Cited by 3 publications

References 38 publications

Iron Nano Biocomposite-Infused Biopolymeric Films: A Multifunctional Approach for Robust Skin Repair

Iron Nano Biocomposite-Infused Biopolymeric Films: A Multifunctional Approach for Robust Skin Repair

Research advancements and perspectives of inflammatory bowel disease: A comprehensive review

Emulgels: a promising topical drug delivery system for arthritis management and care

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