Newly developed mastication activity reduction procedure rapidly induces abnormal atrophic change of the mandibular condyle in young and elder experimental animal models

Matsumoto, K; Amemiya, Toshihiko; Ito, Motohiro; Hayashi, Yusuke; Watanabe, Kenichiro; Dezawa, Ko; Arai, Yoshinori; Honda, Kazumasa

doi:10.2334/josnusd.18-0481

Cited by 3 publications

(5 citation statements)

References 31 publications

(44 reference statements)

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“…Many included studies investigated how the loss of ovarian hormones and reduced masticatory activity negatively impacted the mandible and TMJ. 38–42 …”

Section: Resultsmentioning

confidence: 99%

“…Nevertheless, studies that investigated the relationship between menopause and these structures focused on how the loss of ovarian hormones and reduced masticatory activity negatively impacted mandibular structures, rather than how changes in these bony structures result in disturbances in mastication. 38–42 , 62–66 Therefore, a clear gap in the literature exists regarding how menopause may negatively impact mastication.…”

Section: Discussionmentioning

confidence: 99%

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The Relationship Between Menopause and Dysphagia: A Scoping Review

Lenell

Peña-Chávez

Burdick

et al. 2022

Women's Health Reports

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Purpose: Menopause marks the end of fertility and rapid decline of ovarian hormones in the female body, which corresponds to a myriad of changes to bodily systems, including the upper aerodigestive tract. Despite substantial evidence that menopause negatively impacts oral health, bones, and skeletal muscles, little research has examined these effects as they relate to swallowing. The purpose of this scoping review was to compile and summarize the existing literature investigating the relationship between menopause and swallowing-related structures and physiology. Methods: Search terms were selected for three databases (PubMed, Scopus, and CINAHL) to gather relevant literature evaluating the relationship between menopause and swallowing-related anatomy as well as swallowing functions in both human and animal models. Relevant articles were reviewed, collated, and summarized to synthesize findings, identify gaps in the literature, and provide suggestions for future directions. Results: This scoping review yielded 204 studies with the majority of these studies relating to one or more of the following categories: oral health, saliva, mandibular structures, and taste. Common oral symptoms reported in the literature included xerostomia, hyposalivation, tooth decay, inflammation of oral mucosa, and oral pain. Although literature supports that menopause adversely affects oral health, saliva, mandibular structures, and alters taste, a dearth of information was evident regarding how these hormone-dependent changes can adversely affect swallowing. Conclusions: The relationship between menopause and swallowing has been overlooked by field of speech–language pathology. By identifying the major gaps in the literature, these results will inform future investigations evaluating relationships among ovarian hormones and swallowing.

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“…Many included studies investigated how the loss of ovarian hormones and reduced masticatory activity negatively impacted the mandible and TMJ. 38–42 …”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Relationship Between Menopause and Dysphagia: A Scoping Review

Lenell

Peña-Chávez

Burdick

et al. 2022

Women's Health Reports

View full text Add to dashboard Cite

show abstract

“…Since that region is encompassed by the periodontal ligament, the different mastication forces experienced here could lead to different bone remodeling rates [ 43 ]. Two studies indeed revealed a positive effect of masticatory forces on the jaw bone by delaying bone loss following ageing and ovariectomy and by improving the overall jaw bone quality [ 8 , 57 ]. Finally, analysis of the bone surrounding the mandibular M3 showed that Tb.Pf and SMI of the ovariectomized rats increased by 185% and 243.75% respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Their findings suggest that reduction of appropriate mastication activity in the growth period results in poor growth of the mandibular condyle. Furthermore conditions simulating aged/postmenopausal status induce atrophy of the mandibular condyle [ 57 ]. In our study, it was observed that OVX caused a significant deterioration of the trabecular bone micro-architecture parameters Tb.Pf and SMI when compared to shOVX.…”

Section: Discussionmentioning

confidence: 99%

Is the Jaw Bone Micro-Structure Altered in Response to Osteoporosis and Bisphosphonate Treatment? A Micro-CT Analysis

Chatterjee

Faot

Correa

et al. 2021

IJMS

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The aim of the study was to quantify the micro-architectural changes of the jaw bone in response to ovariectomy, exposed or not to bisphosphonate treatment. A total of 47 Wistar rats were ovariectomized (OVX) or sham-operated (shOVX) and exposed to osteoporosis preventive treatment for eight weeks either with bisphosphonates (alendronate, ALN; group OVX-ALN) three days/week at a dose of 2 mg/kg or with saline solution (untreated control condition; group OVX). The bone morphometric parameters of the trabecular jaw bone were assessed using ex vivo micro-computed tomography. The regions of interest investigated in the maxilla were the inter-radicular septum of the second molar and the tuber. The regions quantified in the mandible included the three molar regions and the condyle. A one-way analysis of variance followed by pairwise comparison using Tukey’s HSD and the Games–Howell test was conducted to explore significant differences between the groups. In the maxilla, OVX decreased the bone volume in the inter-radicular septum of the second molar. Bisphosphonate treatment was able to prevent this deterioration of the jaw bone. The other investigated maxillary regions were not affected by (un)treated ovariectomy. In the mandible, OVX had a significant negative impact on the jaw bone in the buccal region of the first molar and the inter-radicular region of the third molar. Treatment with ALN was able to prevent this jaw bone loss. At the condyle site, OVX significantly deteriorated the trabecular connectivity and shape, whereas preventive bisphosphonate treatment showed a positive effect on this trabecular bone region. No significant results between the groups were observed for the remaining regions of interest. In summary, our results showed that the effects of ovariectomy-induced osteoporosis are manifested at selected jaw bone regions and that bisphosphonate treatment is capable to prevent these oral bone changes.

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“…In the field of functional orthodontics, mastication can activate specific muscular groups, influencing trophism of the bone segment which these muscles are inserted in [1] or originate from [2]. Furthermore, several theories suggest that the stomatognathic apparatus can be meant as an "access door" to the whole body.…”

mentioning

confidence: 99%

Modification of cognitive function induced by a functional orthodontic device

Pach�

2023

ADS

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Chewing is one of the most important orofacial functions. Over the last twenty years, a number of authors have examined the correlation between an efficient chewing function and different aspects of body functions: implementation of cognitive functions, reduction of nociceptive impulse propagation, reduced levels of stress, reduced risk of developing atherosclerosis and desaturation, limitation of eating disorders and constipation. Starting from the above considerations, this study aims at investigating the correlation between occlusal balance -without which there would be no proper mastication -and fundamental aspects as cognitive function, stress, arousal and concentration. For this purpose, we used specific tools and software to observe the electrical activity of the brain in 10 healthy volunteers. All the measurements for each participant have been carried out in three different phases: a first phase in which all the individuals were in a condition of initial occlusion; a second phase in which the occlusion was modified using a functional orthodontic device; and a third phase, in which individuals removed the device. The variations between three phases have been evaluated by using the Student's t-test, and we considered them significant for p<0.05. The results have highlighted a significant variation in terms of stress, arousal and concentration among the three phases.

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Newly developed mastication activity reduction procedure rapidly induces abnormal atrophic change of the mandibular condyle in young and elder experimental animal models

Cited by 3 publications

References 31 publications

The Relationship Between Menopause and Dysphagia: A Scoping Review

The Relationship Between Menopause and Dysphagia: A Scoping Review

Is the Jaw Bone Micro-Structure Altered in Response to Osteoporosis and Bisphosphonate Treatment? A Micro-CT Analysis

Modification of cognitive function induced by a functional orthodontic device

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