Newly designed silver coated-magnetic, monodisperse polymeric microbeads as SERS substrate for low-level detection of amoxicillin

Abstract

We report the preparation of silver-coated magnetic polymethacrylate coreeshell nanoparticles for use in surface-enhanced Raman scattering based drug detection. Monodisperse porous poly (mono-2-(methacryloyloxy)ethyl succinate-co-glycerol dimethacrylate), poly (MMES-co-GDMA) microbeads of ca. 5 mm diameter were first synthesized through a multistage microsuspension polymerization technique to serve as a carboxyl-bearing core region. Microspheres were subsequently magnetized by the coprecipitation of ferric ions, aminated through the surface hydroxyl groups and decorated with Au nanoparticles via electrostatic attraction. An Ag shell was then formed on top of the Au layer through a seed-mediated growth process, resulting in micron-sized monodisperse microbeads that exhibit Raman enhancement effects due to the roughness of the Ag surface layer. The coreeshell microspheres were used as a new substrate for the detection of amoxicillin at trace concentrations up to 10 À8 M by SERS. The proposed SERS platform can be evaluated as a useful tool for the follow-up amoxicillin pollution and lowlevel detection of amoxicillin in aqueous media.

Trends in Application of SERS Substrates beyond Ag and Au, and Their Role in Bioanalysis

“…The Al-doped ZnO@SnO 2 heteronanowires can also be used for trace detection of drugs such as amoxicillin, an antibacterial drug used to treat bacterial infections in animals and humans [ 246 ]. The detection of amoxicillin was down to 10 −10 M, by two orders of magnitude better result compared with the previous report 10 −10 M [ 247 ]. One of the possible reasons for such a low limit of detection could be the optimization of shell-thicknesses of Al-doped ZnO@SnO 2 heteronanowires, which allowed exhibiting a suitable geometry to deposit high-density Ag nanoparticles and hence generate more hot spots in three-dimensional structures.…”

Functionalized Silver Nanocubes for the Detection of Hazardous Analytes through Surface-Enhanced Raman Scattering: Experimental and Computational Studies

“…A concentration of Ag NCs of 1.31 × 10 −3 M was used for the substrate fabrication and detected MB as low as 10 −9 M. 22 Ag-coated magnetic polymethacrylate core−shell NPs were used as the substrate for the detection of MB at 10 −7 M with 70.6 × 10 −6 M Ag loading. 23 The details of composites, concentration of Ag loading, and LOD of MB reported in the literature and present work are compared and tabulated in Table 1 in the Results and Discussion. Other substrates synthesized for SERS application with higher loadings of nanostructures were observed.…”

One‐pot synthesis of organic–inorganic hybrid polyhedral oligomeric silsesquioxane microparticles in a double‐zone temperature controlled microfluidic reactor

“…Organic–inorganic hybrid micro/nanoparticles are one of the most popular materials studied in the last decade because of their multifunctional properties. Due to their organic component, they are biocompatible and have prespecified wetting characteristics (hydrophobic/hydrophilic); in addition to these, their inorganic part gives them unique mechanical, electrical, and magnetic properties . Consequently, they have several potential application areas such as drug delivery, imaging, fuel cells, photocatalysts, cosmetics, packaging .…”