Newly Designed Amperometric Biosensor for Hydrogen Peroxide and Glucose Based on Vanadium Sulfide Nanoparticles

Abstract

In the present work, we describe a facile, green, and template-free solvothermal fabrication of vanadium sulfide (VS2) nanoparticles (NPs) and their application for the electrochemical detection of hydrogen peroxide (H2O2) and glucose. The morphology and composition of as-prepared samples were well-characterized by powder X-ray diffraction, energy-dispersive spectroscopy, transmission electron microscopy, scanning electron microscopy, UV–vis spectroscopy, and Brunauer–Emmett–Teller surface area measurement. Because of their interesting electrochemical responses toward H2O2, a novel nonenzymatic electrochemical sensor for H2O2 and glucose detection has been proposed based on a VS2 NP-modified glassy carbon electrode. The modified electrode showed an excellent electrochemical performance for the selective and sensitive nonenzymatic detection of H2O2 in a broad concentration range of 0.5 μM to 3.0 mM, with a wide linear range of 0.5 μM to 2.5 mM and a lower detection limit of 0.224 μM. The newly developed sensor also displayed high sensitivity (41.96 μA mM–1) toward the detection of glucose with a broad linear range of 0.5 μM to 3 mM. The as-fabricated sensor also showed very high sensitivity, excellent reusability, long-term stability, and negligible interference ability. Moreover, the synthesized NPs were applied for H2O2 and glucose detection in real samples, signifying their potential application in routine H2O2 and glucose analysis. The present study reveals that as-prepared VS2 NPs are promising for electrochemical H2O2 and glucose sensing and other biological applications.

Progress of Advanced Nanomaterials in the Non-Enzymatic Electrochemical Sensing of Glucose and H2O2

“…The developed sensor electrode reported a selective and sensitive non-enzymatic detection of H 2 O 2 with a sensitivity of 41.96 μA mM −1 , linear range of 0.5 μM to 2.5 mM with a lower detection limit of 0.224 μM. The high conductivity, abundant source, and low cost of VS 2 NPs motivated to study NEGH sensing [ 61 ]. Tian et al (2013) converted bulk C 3 N 4 into ultrathin graphitic carbon nitrate (g-C 3 N 4 ) using ultra sonication-assisted liquid exfoliation, which offered a low-cost synthesis method with an efficient electro catalyst for NEGH sensing.…”

Deposition of nanomaterials: A crucial step in biosensor fabrication

“…In addition, extensive efforts have been made to use the drop-casting method to deposit nanomaterials onto a desired electrode surface for sensing applications that include H2O2 [136][137][138][139][140][141][142][143], dopamine [144][145][146][147][148][149][150][151], uric acid [148][149][150][151][152][153][154][155][156][157][158], ascorbic acid [151,[158][159][160], epinephrine [154], L-glutamic acid [155], urea [70, 161,162], HIV gene detection [163], tryptophan [164], cholesterol [165], miRNA [166,167], cysteine [168], estriol [169], ractopamine [170], lactate [171], and ochratoxin A [172]. Several research groups have reviewed nanomaterial-based nonenzymatic and enzymatic biosen...…”

Rational Design of Nanoporous MoS2/VS2 Heteroarchitecture for Ultrahigh Performance Ammonia Sensors

“…TMDs exhibit many attractive characteristics, including tunable layer thickness at nanoscale, large surface‐to‐volume ratio, ease of surface functionalization, and high compatibility for device integration, all of which are crucial for developing high performance sensors toward various analytes 1b. To date, effective TMD‐based sensors, such as MoS 2 , WS 2 , SnS 2 ,1b and VS 2 ,5a,7 have been successively constructed by means of functionalization or structural engineering.…”

“…Heterostructures formed by two TMDs may exhibit features which are unique from their single‐component counterparts,11e and TMD–TMD heterostructures have served as the building blocks for a wide variety of electronic and optoelectronic applications . In this contribution, VS 2 , as another representative member of the TMD family with an intrinsic metallic and highly conductive characteristics,5a,7,12 is used as a scaffold for the epitaxial growth of MoS 2 nanosheets to form a TMD–TMD heterostructure. The porous VS 2 (P‐VS 2 ) scaffold synthesized by using F127 as a structure‐directing agent provides a stable skeleton for the controlled growth or assembly of MoS 2 nanosheets on its surface and inner pores, leading to the formation of structurally stable MoS 2 /VS 2 heterostructure .…”