Newer series of trioxane derivatives as potent antimalarial agents

Rudrapal, Mithun; Banu, Zartaj Washmin; Chetia, Dipak

doi:10.1007/s00044-017-2090-8

Cited by 20 publications

(18 citation statements)

References 38 publications

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“…During the past few decades, the emergence of drug resistant strains of has become an increasingly Plasmodium falciparum serious concern in malaria control and prevention worldwide (Rudrapal and Chetia, 2016a;Rudrapal et al, 2018). Because of this emergence of multi-drug resistant strains of , P. falciparum the development of new and potent antimalarial drugs active against resistant malaria could be a key therapeutic strategy for the control and prevention of malaria (Patowary et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo models used for antimalarial activity: A brief review

Rudrapal¹,

Chetia²

2019

Asian J Pharm Pharmacol

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Section: Introductionmentioning

confidence: 99%

In vitro and in vivo models used for antimalarial activity: A brief review

Rudrapal¹,

Chetia²

2019

Asian J Pharm Pharmacol

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“…Molecular docking was performed for all designed compounds, QI-1 to QI-15 using P. falciparum falcipain 2 enzyme. The x-ray crystal structure of falcipain 2-E-64 (PDB id: 3BPF) was retrieved from the RCSB protein data bank (http://www.rcsb.org/pdb/) and Chain A of the protein determined at a resolution of 2.9 Å was used in the study 4 . After energy minimization, the Chain A of falcipain 2 protein was defined as a receptor and the binding site sphere was selected based on the ligand binding location of E-64.…”

Section: Docking Studymentioning

confidence: 99%

“…This has limited the clinical utility of currently available antimalarial drugs and/or antimalarial drug therapy. Today, the increasing burden of resistant malaria has thus become a serious health concern in malaria control and prevention worldwide [4][5][6] .…”

Section: Introductionmentioning

confidence: 99%

Molecular Docking, Drug-Likeness Studies and ADMET Prediction of Quinoline Imines for Antimalarial Activity

2019

Chem Sci Trans

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A novel series of quinoline imines were designed by molecular manipulation approach using the principle of rational drug design. Newly designed quinoline imines were screened virtually for antimalarial effectiveness and also for drug-likeness using various in silico tools of drug design. The molecular docking was performed against P. falciparum parasite targeting specific cysteine protease falcipain 2 enzyme. In addition, drug-likeness and ADMET prediction studies were carried out using in silico tools. Our study reports antimalarial potential of novel quinoline imines as druglike molecules which can be further developed as potent antimalarial agents (falcipain 2 inhibitors) possibly against resistant P. falciparum parasite.

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“…Therefore, a good drug molecule possesses balanced relationship between lipophilicity and drug activity. 17,18,19,20 In our study, the lipophilicity expressed as clogP o/w (calculated oil/water partition coefficient) value presented in Table 1 indicated that higher the value of clogP, better the antimalarial activity was observed. The compound 4i having optimal lipophilicity with clogP value of 2.88 showed best antimalarial activity in the series.…”

Section: Antimalarial Activitymentioning

confidence: 99%

“…21,22,23 Two strains were used for the study, one is CQ-sensitive 3D-7 and the other is CQ-resistant RKL-2. All the test compounds, 4a-j were initially screened at two fixed doses, 5 µg/ml and 50 µg/ml against CQ-sensitive strain.…”

Section: Antimalarial Activity Evaluationmentioning

confidence: 99%

Synthesis and Antimalarial Activity of Lawsone Mannich Base Derivatives

Arundhati¹,

Chetia²,

Rudrapal³

2018

IJPER

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Introduction:The emergence of multi-drug resistant strains of Plasmodium falciparum has increasingly become a serious health problem worldwide. To address this challenging issue, there is an urgent need to discover and develop novel and potent antimalarial agents. Materials and Methods: A new series of lawsone Mannich base derivatives were synthesized, characterized (IR, NMR and Mass) and evaluated for in vitro for antimalarial activity against chloroquine (CQ)-sensitive and CQ-resistant strains of P. falciparum. Results and Discussion: Among synthesized compounds, five compounds showed good antimalarial activity against both chloroquine (CQ)-sensitive (3D-7) and -resistant (RKL-2) strains of P. falciparum, which, however, was considerably less than that of the standard reference drug, CQ. The antimalarial activity of these five compounds was found better against sensitive (IC 50 = 0.411-0.502 μg/ml) strain than the resistant (IC 50 = 1.391-2.394 μg/ml) one. The IC50 values for CQ were 0.044 μg/ml and 0.216 μg/ml against sensitive and resistant strains of P. falciparum, respectively. SAR study suggests that antimalarial potential of lawsone structural scaffold can be modulated by different substitution pattern like Mannich base substitution (alkyl/aryl/heteroaryl substituted aminoalkyl moiety) at the C-3 position of 1,4-naphthoquinone ring system. Conclusion: Owing to their antimalarial effectiveness, lawsone derived aminonaphthoquinones can be used as lead structure(s) in the development of yet more potent antimalarial agents.

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Newer series of trioxane derivatives as potent antimalarial agents

Cited by 20 publications

References 38 publications

In vitro and in vivo models used for antimalarial activity: A brief review

In vitro and in vivo models used for antimalarial activity: A brief review

Molecular Docking, Drug-Likeness Studies and ADMET Prediction of Quinoline Imines for Antimalarial Activity

Synthesis and Antimalarial Activity of Lawsone Mannich Base Derivatives

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