Newer Immunosuppressants for Rheumatologic Disease

Koh, Ye Rin; Cummings, Kenneth C.

doi:10.1016/j.anclin.2023.07.003

Cited by 1 publication

(2 citation statements)

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“…Systemic antibodies to Aa or LtxA reflect previous immunoreactivity against the bacterium, while detection of the bacterium in the oral cavity shows the presence at the time for sampling [21,29]. These circumstances have to be considered in the interpretation of data from diseases like RA that involve treatment strategies with immunosuppressive effects [46].…”

Section: Discussionmentioning

confidence: 99%

“…Also, DAS28 was similar among RA patients with Aa in saliva (median: 2.8; IQR: 1.9) and RA patients without Aa in saliva (median: 3.2; IQR: 1.3; P = 0.27). 53) 62 ( 50) SC ACPA in serum, median µg/mL (IQR) 52 ( 44) 68 (46) Correlations between detectable salivary Aa and ESR, CRP, oral health and RA treatment were also investigated among the RA patients, as illustrated in Figure 2. No correlations of clinical importance were observed for salivary Aa or LtxA-neutralizing antibodies, besides the moderately strong positive correlation between the two as mentioned above.…”

Section: Association Between Aa and Acpa Disease Activity And Treatme...mentioning

confidence: 99%

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Presence and Immunoreactivity of Aggregatibacter actinomycetemcomitans in Rheumatoid Arthritis

Svärd,

LoMartire,

Martinsson

et al. 2024

Pathogens

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The presence of periodontal pathogens is associated with an increased prevalence of rheumatoid arthritis (RA). The systemic antibody response to epitopes of these bacteria is often used as a proxy to study correlations between bacteria and RA. The primary aim of the present study is to examine the correlation between the presence of Aggregatibacter actinomycetemcomitans (Aa) in the oral cavity and serum antibodies against the leukotoxin (LtxA) produced by this bacterium. The salivary presence of Aa was analyzed with quantitative PCR and serum LtxA ab in a cell culture-based neutralization assay. The analyses were performed on samples from a well-characterized RA cohort (n = 189) and a reference population of blood donors (n = 101). Salivary Aa was present in 15% of the RA patients and 6% of the blood donors. LtxA ab were detected in 19% of RA-sera and in 16% of sera from blood donors. The correlation between salivary Aa and serum LtxA ab was surprisingly low (rho = 0.55 [95% CI: 0.40, 0.68]). The presence of salivary Aa showed no significant association with any of the RA-associated parameters documented in the cohort. A limitation of the present study is the relatively low number of individuals with detectable concentrations of Aa in saliva. Moreover, in the comparison of detectable Aa prevalence between RA patients and blood donors, we assumed that the two groups were equivalent in other Aa prognostic factors. These limitations must be taken into consideration when the result from the study is interpreted. We conclude that a systemic immune response to Aa LtxA does not fully reflect the prevalence of Aa in saliva. In addition, the association between RA-associated parameters and the presence of Aa was negligible in the present RA cohort.

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Section: Discussionmentioning

confidence: 99%

Section: Association Between Aa and Acpa Disease Activity And Treatme...mentioning

confidence: 99%