Newer Developments in Penicillin Immunochemistry

Weck, A.L. de

doi:10.1159/000229368

Cited by 18 publications

(4 citation statements)

References 9 publications

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“…Furthermore, many authors have long suspected BPO groups to be involved in the pathogenesis of penicillin allergy (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Fixation of penicilloyl groups to albumin and appearance of anti-penicilloyl antibodies in penicillin-treated patients.

Lafaye¹,

Lapresle²

1988

J. Clin. Invest.

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Penicilloyl groups, which have been connected to penicillin allergy, are derived from penicillin by cleavage of the v lactam ring and bind covalently to proteins. Fixation of penicilloyl groups was studied in seven patients given large amounts of penicillin. Penicilloyl groups were found essentially on the albumin molecule at sites not accessible to anti-penicilloyl antibodies, except after pronase digestion. The amount of penicilloyl groups was proportional to the cumulated doses of penicillin. The decline of penicilloyl groups with time after treatment interruption was exponential. The half-life of penicilloylated albumin was lower than or equal to that of normal albumin. The presence of anti-penicilloyl antibodies was demonstrated in 19 out of 34 penicillin-treated patients (including the seven mentioned above). The relative scarcity of penicillin allergy as compared with the frequent occurrence of anti-penicilloyl antibodies may be partly related to unavailable sites of penicilloyl groups within the albumin molecule.

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“…Furthermore, many authors have long suspected BPO groups to be involved in the pathogenesis of penicillin allergy (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Fixation of penicilloyl groups to albumin and appearance of anti-penicilloyl antibodies in penicillin-treated patients.

Lafaye¹,

Lapresle²

1988

J. Clin. Invest.

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“…This inform ation was obtained from experim ental data in man and animals, and has led to the m anufacture of penicilloyl-polylysine, a compound in which penicilloyl groups have been linked to polylysine in the same configuration in which the penicilloyl group is thought to be linked to lysine amino groups of tissue proteins in vivo [2,5,8]. In contrast, those other antigenic determ inants which are characteristic of deg radation products derived from the penicillin molecule and to which skin sensitivity is not detected by testing with penicilloyl-polylysine are less frequently involved in penicillin sensitivity.…”

Section: Rearranges (1) Penicillin G --------------► D-benzylpenicillmentioning

confidence: 99%

Allergic Cutaneous Reactions to Penicillin and their Mechanisms

Fellner¹,

Baer²

1967

Dermatology

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“…Such a view seems to be now widely accepted, as well as the 'allergenic equiva lence' (1) between PN and PNCE. In 1962 we pointed out (23,28) however that alternate pathways for the formation of PNCOyl antigens had to be considered as soon as it is no longer dealt ex clusively with benzylpenicillin.…”

Section: The Formation Of Pncoyl Antigenic Conjugates From Pnmentioning

confidence: 99%