Newer antipsychotics and the rabbit syndrome

Dell’Osso, Mario Catena; Fagiolini, Andrea; Ducci, Francesca; Masalehdan, Azadeh; Ciapparelli, Antonio; Frank, Ellen

doi:10.1186/1745-0179-3-6

Cited by 27 publications

(23 citation statements)

References 31 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It classically occurs after long-term use (months to years) of antipsychotics antagonising dopaminergic receptors, with a prevalence of 2.3–4.4% in treated patients 37. In addition, cases unrelated to neuroleptic exposure were reported to occur with imipramine, citalopram, paroxetine, methylphenidate and phenol intoxication 38. Rabbit syndrome consists of fine rhythmic movements (5 Hz) at rest involving only the vertical axis of the oral, perinasal and masticatory muscles.…”

Section: Unusual Tremor Syndromesmentioning

confidence: 99%

Unusual tremor syndromes: know in order to recognise

Ure

Dhanju

Lang

et al. 2016

J Neurol Neurosurg Psychiatry

View full text Add to dashboard Cite

Tremor is a common neurological condition in clinical practice; yet, few syndromes are widely recognised and discussed in the literature. As a result, there is an overdiagnosis of well-known causes, such as essential tremor. Many important unusual syndromes should be considered in the differential diagnosis of patients with tremor. The objective of this review is to provide broad clinical information to aid in the recognition and treatment of various unusual tremor syndromes in the adult and paediatric populations. The review comprised of a comprehensive online search using PubMed, Ovid database and Google Scholar to identify the available literature for each unusual tremor syndrome. The review includes fragile X-associated tremor/ataxia syndrome, spinocerebellar ataxia type 12, tremors caused by autosomal recessive cerebellar ataxias, myorhythmia, isolated tongue tremor, Wilson's disease, slow orthostatic tremor, peripheral trauma-induced tremor, tardive tremor and rabbit syndrome, paroxysmal tremors (hereditary chin tremor, bilateral high-frequency synchronous discharges, head tremor, limb-shaking transient ischaemic attack), bobble-head doll syndrome, spasmus nutans and shuddering attacks. Rare tremors generally present with an action tremor and a variable combination of postural and kinetic components with resting tremors less frequently seen. The phenomenology of myorhythmia is still vague and a clinical definition is proposed. The recognition of these entities should facilitate the correct diagnosis and guide the physician to a prompt intervention.

show abstract

Section: Unusual Tremor Syndromesmentioning

confidence: 99%

Unusual tremor syndromes: know in order to recognise

Ure

Dhanju

Lang

et al. 2016

J Neurol Neurosurg Psychiatry

View full text Add to dashboard Cite

show abstract

“…In the recent past, RS was also observed in patients treated with the newer antipsychotics. 6 , 13 RS responds well to treatment with anticholinergic agents. 3 RS typically disappears a few days after the introduction of an anticholinergic agent, but can, on occasion, reappear after stopping anticholinergic medications.…”

Section: Discussionmentioning

confidence: 95%

“…Risperidone is considered the atypical antipsychotic with the highest incidence of extrapyramidal symptoms (EPS). 5 An extensive literature search revealed 11 cases of RS related to newer antipsychotic studies reported by Dell'Osso et al 6 Eight of the 11 reported cases of RS are linked to risperidone. 6-12 The 3 remaining cases occurred with clozapine, olanzapine, and aripiprazole, respectively.…”

Section: Introductionmentioning

confidence: 99%

“…It is interesting that, in the case induced by clozapine, TD preceded RS which developed after treatment for approximately two years with chlorpromazine, haloperidol, and fluphenazine decanoate, either in monotherapy or in combination. 6 In addition, there are 3 new case reports concerning EPS, which include RS associated with aripiprazole and olanzapine. 16-18 …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clozapine-induced rabbit syndrome: a case report

Hocaoğlu

2009

Mental Illness

View full text Add to dashboard Cite

Rabbit syndrome (RS) is an antipsychotic-induced rhythmic motion of the mouth/lips resembling the chewing movements of a rabbit. The movement consists of a vertical-only motion, at about 5 Hz, with no involvement of the tongue. Long-term exposure to typical antipsychotics has clearly been associated with RS, but little is known of the risk of RS due to exposure to newer atypical antipsychotics. There have been isolated reports of RS in patients treated with the atypical agents risperidone, aripiprazole, olanzapine, and clozapine. We present the case history of a 44-year old female patient treated for paranoid schizophrenia for 22 years and RS during her last 10-month clozapine treatment. Background information from the literature is also discussed.

show abstract

“…The mechanism of quetiapine-related RS is unclear. It has been demonstrated that atypical antipsychotics including: risperidone, clozapine and aripiprazole may increase RS risk in the literature (4). Tardive dyskinesia related to quetiapine has been demonstrated also in several cases (5).…”

Section: Case Reportmentioning

confidence: 99%