Newcastle disease virus nucleocapsid protein mediates the degradation of 14–3–3ε to antagonize the interferon response and promote viral replication

Song, Yong; Liang, Jianpeng; Jin, Jiaqi; Wu, Wei; Ren, Jing; Ruan, Jiayu; Fan, Lei; Yuan, Weifeng; Cai, Juncheng; Lin, Qiuyan; Xiang, Bin; Ding, Chan; Ren, Tao; Chen, Libin

doi:10.1016/j.vetmic.2023.109851

Cited by 2 publications

(1 citation statement)

References 35 publications

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“…14–3–3ε, known for its interactions with retinoic acid-inducible gene I (RIG-I) and mitochondrial antiviral signalling protein (MAVS), serves as a crucial component within IFN-related host cascades [ 34 ]. Xu et al [ 35 ] investigated the role of 14–3–3ε in NDV infection and observed that viral replication was promoted via the enhanced degradation of 14–3–3ε. Meanwhile, activation of the IFN pathway necessitated the presence of 14-3-3ε, which facilitated the interaction between MDA5 and MAVS during NDV infection.…”

Section: Main Textmentioning

confidence: 99%

The multifaceted interactions between Newcastle disease virus proteins and host proteins: a systematic review

Lu,

Wang,

Liu

et al. 2024

Virulence

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Newcastle disease virus (NDV) typically induces severe illness in poultry and results in significant economic losses for the worldwide poultry sector. NDV, an RNA virus with a single-stranded negative-sense genome, is susceptible to mutation and immune evasion during viral transmission, thus imposing enormous challenges to avian health and poultry production. NDV is composed of six structural proteins and two nonstructural proteins that exert pivotal roles in viral infection and antiviral responses by interacting with host proteins. Nowadays, there is a particular focus on the mechanisms of virus-host protein interactions in NDV research, yet a comprehensive overview of such research is still lacking. Herein, we briefly summarize the mechanisms regarding the effects of virus-host protein interaction on viral infection, pathogenesis, and host immune responses. This review can not only enhance the present comprehension of the mechanism underlying NDV and host interplay, but also furnish a point of reference for the advancement of antiviral measures.

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Section: Main Textmentioning

confidence: 99%

The multifaceted interactions between Newcastle disease virus proteins and host proteins: a systematic review

Lu,

Wang,

Liu

et al. 2024

Virulence

View full text Add to dashboard Cite

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The NP protein of Newcastle disease virus dictates its oncolytic activity by regulating viral mRNA translation efficiency

Liao,

Chen,

Guo

et al. 2024

PLoS Pathog

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Newcastle disease virus (NDV) has been extensively studied as a promising oncolytic virus for killing tumor cells in vitro and in vivo in clinical trials. However, the viral components that regulate the oncolytic activity of NDV remain incompletely understood. In this study, we systematically compared the replication ability of different NDV genotypes in various tumor cells and identified NP protein determines the oncolytic activity of NDV. On the one hand, NDV strains with phenylalanine (F) at the 450th amino acid position of the NP protein (450th-F-NP) exhibit a loss of oncolytic activity. This phenotype is predominantly associated with genotype VII NDVs. In contrast, the NP protein with a leucine amino acid at this site in other genotypes (450th-L-NP) can facilitate the loading of viral mRNA onto ribosomes more effectively than 450th-F-NP. On the other hand, the NP protein from NDV strains that exhibit strong oncogenicity interacts with eIF4A1 within its 366–489 amino acid region, leading to the inhibition of cellular mRNA translation with a complex 5’ UTR structure. Our study provide mechanistic insights into how highly oncolytic NDV strains selectively promote the translation of viral mRNA and will also facilitate the screening of oncolytic strains for oncolytic therapy.

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Newcastle disease virus nucleocapsid protein mediates the degradation of 14–3–3ε to antagonize the interferon response and promote viral replication

Cited by 2 publications

References 35 publications

The multifaceted interactions between Newcastle disease virus proteins and host proteins: a systematic review

The multifaceted interactions between Newcastle disease virus proteins and host proteins: a systematic review

The NP protein of Newcastle disease virus dictates its oncolytic activity by regulating viral mRNA translation efficiency

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