2017
DOI: 10.1002/ijc.31026
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Newcastle disease virus mediates pancreatic tumor rejection via NK cell activation and prevents cancer relapse by prompting adaptive immunity

Abstract: Pancreatic cancer is the 8th most common cause of cancer-related deaths worldwide and the tumor with the poorest prognosis of all solid malignancies. In 1957, it was discovered that Newcastle disease virus (NDV) has oncolytic properties on tumor cells. To study the oncolytic properties of NDV in pancreatic cancer a single dose was administered intravenously in a syngeneic orthotopic tumor model using two different murine pancreatic adenocarcinoma cell lines (DT6606PDA, Panc02). Tumor growth was monitored and i… Show more

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Cited by 27 publications
(23 citation statements)
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“…However, it is also important to note that HSV will initially engage an immunologically suppressive TME comprising Tregs, myeloid-derived suppressor cells (MDSCs), and M2-polarized macrophages; however, despite this, HSV has the capacity to modulate the TME 4 to enrich levels of melanoma-specific effector T cells and decrease levels of Tregs at the site of tumor viral injection 7 . Interestingly, HSV has been reported to inactivate MDSCs, 42 and it is possible that HSV injection could increase NK cell infiltration at the tumor site, as described for alternative OVs, 43 but this remains undescribed for T-Vec.…”
Section: Discussionmentioning
confidence: 99%
“…However, it is also important to note that HSV will initially engage an immunologically suppressive TME comprising Tregs, myeloid-derived suppressor cells (MDSCs), and M2-polarized macrophages; however, despite this, HSV has the capacity to modulate the TME 4 to enrich levels of melanoma-specific effector T cells and decrease levels of Tregs at the site of tumor viral injection 7 . Interestingly, HSV has been reported to inactivate MDSCs, 42 and it is possible that HSV injection could increase NK cell infiltration at the tumor site, as described for alternative OVs, 43 but this remains undescribed for T-Vec.…”
Section: Discussionmentioning
confidence: 99%
“…NDV elicits both an innate and adaptive immune response in the TME by inducing IFN production and immune cell infiltration and maturation 7, 8, 9, 11, 12. In this study, local injection of NDV in HCC induced an immune response and infiltration of CD8 + T and NK cells in the TME.…”
Section: Discussionmentioning
confidence: 50%
“…In both preclinical and clinical studies, NDV induced the production of type I IFNs and is an effective oncolytic agent with a good safety record 7, 8, 9. On one hand, NDV induces both extrinsic and intrinsic apoptosis of malignant cells, 10 and on the other hand, NDV infection elicits both innate and adaptive antiviral immunity, resulting in cross-activated antitumor immune responses 11, 12. Localized therapy with oncolytic NDV induces an inflammatory response, leading to lymphocyte (NK1.1 + , CD3 + CD8 + , and CD11b + lymphocytes, and monocytes) infiltration and an antitumor effect in distant (nonvirally injected) tumors without dissemination of the virus.…”
Section: Introductionmentioning
confidence: 99%
“…Not all HPACs had functional defects in the interferon pathway [45]. In vivo studies revealed NK cell activation by NDV in HPACs and importance of an adaptive T cell mediated immune response [46].…”
Section: Anti-neoplastic and Immune-stimulating Effectsmentioning
confidence: 99%