Newborns at high risk for brain injury: the role of the amplitude-integrated electroencephalography

Variane, Gabriel Fernando Todeschi; Rodrigues, Daniela Pereira; Pietrobom, Rafaela Fabri Rodrigues; França, Carolina Nunes; Netto, Alexandre; Magalhães, Maurício

doi:10.1016/j.jped.2021.10.008

Cited by 7 publications

(4 citation statements)

References 65 publications

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“…To achieve continuous and convenient monitoring, researchers have developed and promoted amplitude-integrated EEG (aEEG), which can be recorded and interpreted independently by observers without expert knowledge. Amplitude-integrated EEGs have been applied in many areas to recognize neonatal brain functional state [2][3], and gained much attention in clinical over the past decades. Nevertheless, research on computer-aided automatic analysis of aEEGs is still at the early stages.…”

Section: Introductionmentioning

confidence: 99%

Multi-scale transformation-based image representation and analysis of amplitude-integrated EEG

Wu,

Chen,

2023

Second International Conference on Biomedical and Intelligent Systems (IC-BIS 2023)

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Section: Introductionmentioning

confidence: 99%

Multi-scale transformation-based image representation and analysis of amplitude-integrated EEG

Wu,

Chen,

2023

Second International Conference on Biomedical and Intelligent Systems (IC-BIS 2023)

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“…Cerebral monitoring of the aEEG trend for seizure detection and evaluation of cortical activity, e.g., the presence of sleep-wake cycling is routinely performed in the NICU [ 16 , 17 , 18 , 19 ]. While aEEG is effective for a general qualitative clinical bedside assessment, the aEEG interpretation is still a subjective assessment with a substantial inter-rater variation and consequently poor sensitivity to those effects that may accompany drug treatment or other therapeutic maneuvers [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

A Bedside Method for Measuring Effects of a Sedative Drug on Cerebral Function in Newborn Infants

Nilsson

Tokariev

Metsäranta

et al. 2022

Sensors

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Background: Data on the cerebral effects of analgesic and sedative drugs are needed for the development of safe and effective treatments during neonatal intensive care. Electroencephalography (EEG) is an objective, but interpreter-dependent method for monitoring cortical activity. Quantitative computerized analyses might reveal EEG changes otherwise not detectable. Methods: EEG registrations were retrospectively collected from 21 infants (mean 38.7 gestational weeks; range 27–42) who received dexmedetomidine during neonatal care. The registrations were transformed into computational features and analyzed visually, and with two computational measures quantifying relative and absolute changes in power (range EEG; rEEG) and cortico-cortical synchrony (activation synchrony index; ASI), respectively. Results: The visual assessment did not reveal any drug effects. In rEEG analyses, a negative correlation was found between the baseline and the referential frontal (rho = 0.612, p = 0.006) and parietal (rho = −0.489, p = 0.035) derivations. The change in ASI was negatively correlated to baseline values in the interhemispheric (rho = −0.753; p = 0.001) and frontal comparisons (rho = −0.496; p = 0.038). Conclusion: Cerebral effects of dexmedetomidine as determined by EEG in newborn infants are related to cortical activity prior to DEX administration, indicating that higher brain activity levels (higher rEEG) during baseline links to a more pronounced reduction by DEX. The computational measurements indicate drug effects on both overall cortical activity and cortico-cortical communication. These effects were not evident in visual analysis.

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“…In its simplest form, aEEG is a processed single-channel electroencephalogram that is filtered and time-compressed. 3,4 Amplitude-integrated electroencephalography is complementary to cEEG and has the advantage of being easier to apply and interpret by non-neurophysiologists (Figure 1). 1 Initially developed and introduced to monitor cerebral activity in encephalopathic adult patients and during anesthesia, aEEG has been used increasingly in some neonatal centers to follow hypoxic-ischemic brain injury, detect seizures that are primarily perirolandic in origin, monitor the effects of different interventions and events on neonatal cerebral activity, and help predict neurodevelopmental outcome.…”

mentioning

confidence: 99%

“…2 Neonatal aEEG has been correlated with gestational age and maturity of preterm and term infants' electrical brain activity. [4][5][6] In Canada, aEEG is routinely used in 94 percent of tertiary NICUs. 7 In a survey of practices in the United States in 2015, 61 percent of academic/university-affiliated NICUs were routinely using aEEG.…”

mentioning

confidence: 99%

Introduction of Amplitude-Integrated Electroencephalography (aEEG) Monitoring in a Level 2 NICU: Improving the Quality of Care for Neurologically At-Risk Newborns

Feldman,

Baisie,

El Shahed

et al. 2023

Neonatal Network

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Amplitude-integrated electroencephalography (aEEG) is a bedside tool for continuous monitoring of brain activity with the possibility of real-time interpretation. Amplitude-integrated electroencephalography is routinely used in Canadian tertiary NICUs; however, its use in Level 2 NICUs has been limited. A bedside aEEG program was introduced in a Level 2 NICU in order to help facilitate the timely transfer of neurologically compromised infants and keep mother–infant dyads together where reassurance of appropriate neurological status could be attained. A monitoring guideline and educational program were developed. The introduction of aEEG monitoring enhanced the care provided to neurologically at-risk newborns. This experience can be used as a framework for other Level 2 NICUs who may wish to embark upon a similar initiative.

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Newborns at high risk for brain injury: the role of the amplitude-integrated electroencephalography

Cited by 7 publications

References 65 publications

Multi-scale transformation-based image representation and analysis of amplitude-integrated EEG

Multi-scale transformation-based image representation and analysis of amplitude-integrated EEG

A Bedside Method for Measuring Effects of a Sedative Drug on Cerebral Function in Newborn Infants

Introduction of Amplitude-Integrated Electroencephalography (aEEG) Monitoring in a Level 2 NICU: Improving the Quality of Care for Neurologically At-Risk Newborns

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