Newborn thyroxine levels and childhood ADHD

Nandedkar, Arvind K.N.; Japal, Knoxley M.; Stein, Mark A.; Mosee, Shiela; Magrab, Phyllis R.; Lai, Shenghan; Lamm, Steven H.

doi:10.1016/s0009-9120(02)00284-9

Cited by 10 publications

(13 citation statements)

References 54 publications

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“…Previous literature regarding associations of T 4 among infants born at term with later developmental outcomes is limited. In one study of 52 cases, each matched with one to five controls, risk for attention deficit hyperactivity disorder was not associated with newborn T 4 levels (32). All of the children in that study had T 4 levels within normal limits.…”

Section: Discussionmentioning

confidence: 89%

Neonatal Thyroxine, Maternal Thyroid Function, and Child Cognition

Oken

Braverman

Platek

et al. 2009

The Journal of Clinical Endocrinology &Amp; Metabolism

118

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Section: Discussionmentioning

confidence: 89%

Neonatal Thyroxine, Maternal Thyroid Function, and Child Cognition

Oken

Braverman

Platek

et al. 2009

The Journal of Clinical Endocrinology &Amp; Metabolism

118

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“…They have not been designed to examine for an association between children diagnosed with ADHD or autism and prior, particularly neonatal, thyroid function status. The only studies that have examined that issue are the case‐control studies by Soldin et al (2002, 2003). Those studies, furthermore, were conducted in Washington, DC, where no thyrotropic environmental exposures are known.…”

Section: Discussionmentioning

confidence: 99%

Pediatric neurobehavioral diseases in Nevada counties with respect to perchlorate in drinking water: An ecological inquiry

Chang

Crothers

Lai

et al. 2003

Birth Defects Research

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This ecological study of children in the exposure area did not find evidence of an increased risk of either ADHD or of autism caused by perchlorate contamination in the drinking water. Furthermore, no difference in overall fourth-grade school performance was observed. No evidence was found that children from the area with perchlorate in the drinking water (up to 24 microg/liter) had either an increase in pediatric neurobehavioral disease (ADHD and autism) or a decrease in fourth-grade academic performance. The limitations of this ecological study relate to diagnostic criteria and ascertainment of geographic and demographic differences and to data on individual residence and water consumption during pregnancy.

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“…Excessive thyroid hormone may present a theoretical risk for children with ADHD; however, neither insufficient nor excessive T 4 levels have been associated with this problem [101] or with other neurobehavioral disorders like autism [107]. Inadvertent administration of a 10-fold excess of T 4 has not been reported to produce any immediate adverse effects [12].…”

Section: Newborns Exposed To Excessive Thyroid Hormone -Minimum Riskmentioning

confidence: 99%

Clinical importance of hypothyroxinemia in the preterm infant and a discussion of treatment concerns

Gamma

Paneth

2012

Current Opinion in Pediatrics

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With 25 000 neonates born in less than 28 weeks each year in the USA, the economic impact of the very high rates of cognitive disabilities and related neurological dysfunction in survivors is substantial. The lifetime direct and indirect costs of CP are estimated at US$1 million per person and the costs of mental retardation are even higher. If reversal of transient hypothyroxinemia proves effective in reducing the risks of CP or mental retardation in ELGANs by 30%, we estimate an overall saving of US$ 3 billion per year. There is a pressing need for a phase III trial of thyroid hormone that is of sufficient duration and size to determine whether a clinically important reduction in risk of developmental impairments in ELGANs can be achieved.

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Newborn thyroxine levels and childhood ADHD

Abstract: Children diagnosed with ADHD do not demonstrate prenatal thyroidal dysfunction as reflected in the newborn thyroxine levels, therefore neonatal thyroxine levels are not a bio-marker for the subsequent development of ADHD.

Cited by 10 publications

References 54 publications

Neonatal Thyroxine, Maternal Thyroid Function, and Child Cognition

Neonatal Thyroxine, Maternal Thyroid Function, and Child Cognition

Pediatric neurobehavioral diseases in Nevada counties with respect to perchlorate in drinking water: An ecological inquiry

Clinical importance of hypothyroxinemia in the preterm infant and a discussion of treatment concerns

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