“…Ensuring a delicate balance between the benefits of early diagnosis and the potential negative effects on quality of life necessitates the implementation of comprehensive psychosocial follow-up programs for affected individuals and their families, in particular when late or uncertain onset is predicted. Unlike other disorders discussed as candidates for NBS programs, such as Krabbe disease [71], the exclusion of late-onset subtypes in MLD is not applicable. The primary reason for this is that predicting purely adult onset is currently not feasible based on genotype or other biomarkers.…”