Newborn screen metabolic panels reflect the impact of common disorders of pregnancy

Reiss, Jonathan; Chang, Alan L.; Mayo, Jonathan A.; Bianco, Katherine; Lee, Henry; Stevenson, David K.; Shaw, Gary M.; Aghaeepour, Nima; Sylvester, Karl G.

doi:10.1038/s41390-021-01753-7

Cited by 2 publications

(1 citation statement)

References 61 publications

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“…Recent in vitro studies have linked increased CPT1A expression in the placenta to the development of pre-eclampsia by inhibition of trophoblast cell invasion and migration [45]. Consistent with this theory, maternal and umbilical cord serum carnitine and acyl-carnitine levels increase in pre-eclampsia [46][47][48][49]. In addition, a maternal high-fat diet in rats downregulated the mRNA and protein expressions of CPT2 in the placenta [50].…”

Section: Interpretation Of Resultsmentioning

confidence: 84%

Decreased Fatty Acid Oxidation Gene Expression in Pre-Eclampsia According to the Onset and Presence of Intrauterine Growth Restriction

Abascal-Saiz,

Fuente-Luelmo,

Haro

et al. 2023

Nutrients

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Mitochondrial fatty acid oxidation (FAO) is lower in placentas with pre-eclampsia. The aim of our study was to compare the placental mRNA expression of FAO enzymes in healthy pregnancies vs. different subgroups of pre-eclampsia according to the severity, time of onset, and the presence of intrauterine growth restriction (IUGR). By using real-time qPCR, we measured the mRNA levels of long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD), medium-chain acyl-CoA dehydrogenase (MCAD), and carnitine palmitoyltransferases 1A and 2 (CPT1A, CPT2) on the maternal side (anchoring villi in the basal decidua) and on the fetal side (chorionic plate) of the placenta (n = 56). When compared to the controls, LCHAD, MCAD, and CPT2 mRNA had decreased in all pre-eclampsia subgroups globally and on the fetal side. On the maternal side, LCHAD mRNA was also lower in all pre-eclampsia subgroups; however, MCAD and CPT2 mRNA were only reduced in severe and early-onset disease, as well as CPT2 in IUGR (p < 0.05). There were no differences in CPT1A mRNA expression. We conclude that the FAO enzymes mRNA in the placenta was lower in pre-eclampsia, with higher reductions observed in severe, early-onset, and IUGR cases and more striking reductions on the fetal side.

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Section: Interpretation Of Resultsmentioning

confidence: 84%

Decreased Fatty Acid Oxidation Gene Expression in Pre-Eclampsia According to the Onset and Presence of Intrauterine Growth Restriction

Abascal-Saiz,

Fuente-Luelmo,

Haro

et al. 2023

Nutrients

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Common Clinical Scenarios of Systemic Hypertension in the NICU

Gaffar,

Ramanathan,

Easterlin

2024

NeoReviews

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Hypertension affects ∼1% to 3% of newborns in the NICU. However, the identification and management of hypertension can be challenging because of the lack of data-driven diagnostic criteria and management guidelines. In this review, we summarize the most recent approaches to diagnosis, evaluation, and treatment of hypertension in neonates and infants. We also identify common clinical conditions in neonates in whom hypertension occurs, such as renal vascular and parenchymal disease, bronchopulmonary dysplasia, and cardiac conditions, and address specific considerations for the evaluation and treatment of hypertension in those conditions. Finally, we discuss the importance of ongoing monitoring and long-term follow-up of infants diagnosed with hypertension.

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Newborn screen metabolic panels reflect the impact of common disorders of pregnancy

Cited by 2 publications

References 61 publications

Decreased Fatty Acid Oxidation Gene Expression in Pre-Eclampsia According to the Onset and Presence of Intrauterine Growth Restriction

Decreased Fatty Acid Oxidation Gene Expression in Pre-Eclampsia According to the Onset and Presence of Intrauterine Growth Restriction

Common Clinical Scenarios of Systemic Hypertension in the NICU

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