Newborn Cystic Fibrosis Diagnosis Made Accurate and Efficient with Machine Learning to Reduce False Positives in IRT-Trypsinogen Immunoreactive Screening Program
Paulo Rogério Siqueira Custódio,
Virginia Klausner,
Rainara Moreno Sanches de Almeida
Abstract:This paper presents a methodology for developing a predictive model using random forests to identify true positive cases of cystic fibrosis in neonatal screening, aiming to improve early detection and care for patients. The current heel prick test used in Brazilian neonatal screening has a high incidence of false positives, leading to unnecessary anxiety and medical interventions for patients and their families. Our methodology, developed using synthetic data and varied model parameters, showed promising resul… Show more
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