New zebrafish genome resources

Burgess, Darren J.

doi:10.1038/nrg3500

Cited by 1 publication

(1 citation statement)

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“…The premise is that the gene signaling we explore is conserved between zebrafish and humans. There is a strong advantage in the zebrafish model because the zebrafish genome was revealed to have exceedingly high homology with the human genome (Burgess, 2013 ; Howe et al, 2013 ). For instance, researchers discovered that zebrafish cxcr4 ( cxcr4b ) is highly expressed in neutrophils and controls neutrophil number and motility and that neutrophils interact with cancer cells to initiate early metastatic events.…”

Section: The Zebrafish Model In Studies Of the Tumor Microenvironmentmentioning

confidence: 99%

Benefits of Zebrafish Xenograft Models in Cancer Research

Chen

Yao

et al. 2021

Front. Cell Dev. Biol.

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As a promising in vivo tool for cancer research, zebrafish have been widely applied in various tumor studies. The zebrafish xenograft model is a low-cost, high-throughput tool for cancer research that can be established quickly and requires only a small sample size, which makes it favorite among researchers. Zebrafish patient-derived xenograft (zPDX) models provide promising evidence for short-term clinical treatment. In this review, we discuss the characteristics and advantages of zebrafish, such as their transparent and translucent features, the use of vascular fluorescence imaging, the establishment of metastatic and intracranial orthotopic models, individual pharmacokinetics measurements, and tumor microenvironment. Furthermore, we introduce how these characteristics and advantages are applied other in tumor studies. Finally, we discuss the future direction of the use of zebrafish in tumor studies and provide new ideas for the application of it.

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Section: The Zebrafish Model In Studies Of the Tumor Microenvironmentmentioning

confidence: 99%