New York clinical criteria for ankylosing spondylitis. A statistical evaluation.

Moll, J. M. H.; Wright, V.

doi:10.1136/ard.32.4.354

Cited by 206 publications

(73 citation statements)

References 10 publications

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“…All PsA patients met the Moll-Wright criteria (13). All SNSA patients had sacroiliitis; 4 of the SNSA patients (3 men, 1 woman) were suspected of having ankylosing spondylitis, but they did not meet the New York criteria (14). OA patients did not show any signs of inflammation; their erythrocyte sedimentation rates (ESRs) were Ͻ30 mm/hour.…”

Section: Methodsmentioning

confidence: 99%

Synovial fluid exoglycosidases are predictors of rheumatoid arthritis and are effective in cartilage glycosaminoglycan depletion

Ortutay

Polgar

Gömör³

et al. 2003

Arthritis & Rheumatism

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Objective. To analyze enzymes involved in joint damage by simultaneous investigation of glycosidases and matrix metalloproteinases (MMPs) in patients with various joint diseases. In joint diseases, the major clinical symptoms and disability of patients are caused by an irreversible destruction of hyaline cartilage. Enzymes capable of degrading extracellular matrix components (collagen and aggrecan) and concomitantly exposing chondrocytes to a variety of cytotoxic and/or apoptosis-inducing factors are considered to be the major effector molecules in cartilage degradation. Methods. Activities of glycosidases (␤-DRecently, significant advances have been made in our understanding of joint destruction and the mechanism of proteolytic cleavage of cartilage. Active proteases are currently implicated in the destructive processes and include matrix metalloproteinases (MMPs), the ADAM family (1), the ADAM-TS family (2), and serine proteases (elastase, cathepsins, and granzymes) (3-5). Of the 4 groups of MMPs, collagenase (MMP-1 in particular) appears to be responsible for the degradation of interstitial collagens. The gelatinases (including MMP-2 and MMP-9) degrade the denatured form of collagens, thus acting in synergy with MMP-1. The stromelysins (including MMP-3) have a broader substrate specificity for non-connective tissue components.

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Section: Methodsmentioning

confidence: 99%

Synovial fluid exoglycosidases are predictors of rheumatoid arthritis and are effective in cartilage glycosaminoglycan depletion

Ortutay

Polgar

Gömör³

et al. 2003

Arthritis & Rheumatism

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“…The medical records of patients identified as possible cases were then reviewed by the investigators. Those patients considered likely to have SpA were invited to attend special clinics for interview and examination in order to verify their diagnoses and collect the data necessary for evaluating the ESSG criteria All 104 patients included in this study fulfilled one of the following sets of criteria: for AS, the New York criteria (8); for RS, the 1982 preliminary criteria of the American College of Rheumatology (ACR) (formerly, the American Rheumatism Association) (9); for IBD-related arthritis, PsA, and ReA following dysenteric illness, the diagnostic guidelines specified in the ninth edition of the Primer on the Rheumatic Diseases (lo), or for USpA, our previously developed working criteria (3,4). These working criteria consisted of objective evidence of inflammatory joint involvement observed by a physician plus any 3 items from the following list: as part of the presenting illness, asymmetric joint involvement, predominantly of the lower extremities; enthesopathy; sterile joint effusion; persistent low back pain or physical findings consistent with sacroiliitis; mild anemia and elevated erythrocyte sedimentation rate, not accounted for by the presence of other disease; or, based on historical information in the patient's medical record, evidence of an intermittent disease course, with recurrent episodes of joint involvement or the occurrence of iritis or uveitis, diagnosed by a physician.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of the european spondylarthropathy study group preliminary classification criteria in alaskan eskimo populations

Boyer

Templin

Goring

1993

Arthritis & Rheumatism

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Objective. To evaluate the preliminary classification criteria proposed by the European Spondylarthropathy Study Group (ESSG) in Alaskan Eskimo populations.Methods. We examined, interviewed, and reviewed the records of 104 Eskimo patients with spondylarthropathy and 75 with other rheumatic disorders, and evaluated them according to the proposed criteria.Results. We found an overall sensitivity of 88.5% and a specificity of 89.3%, which is similar to the reported values in European populations.Conclusion. The ESSG criteria performed well in a population very different from that in which they were developed, and deserve further evaluation as a muchneeded and useful epidemiologic tool.Epidemiologic studies of the diseases which make up the spondylarthropathies (SpA) have been hampered by the lack of adequate disease criteria (1-4). In earlier studies of rheumatic disease prevalence in native populations of Alaska, we found that (3,4). Recently, the European Spondylarthropathy Study Group (ESSG) developed classification criteria intended to encompass a broader spectrum of spondylarthropathic disease, with the specific intent of including previously neglected cases of undifferentiated disease (5). We have tested these criteria in a wide variety of rheumatic disorders in Alaskan Eskimos, in order to contribute to the necessary validation of these preliminary criteria. We report the results of our evaluation herein. PATIENTS AND METHODSA total of 104 patients with SPA were included in the evaluation. Sixty-six patients were identified during ongoing epidemiologic studies in the Barrow and Bristol Bay Health Service Units of the Alaska Area Native Health Service (AANHS), and 38 patients were known cases from previous epidemiologic studies in Kotzebue and the YukonKuskowim Delta (3,4). Initial identification of possible cases in the Barrow and Bristol Bay areas was accomplished primarily through the computerized patient care information system used by the AANHS (6,7). The medical records of patients identified as possible cases were then reviewed by the investigators. Those patients considered likely to have SpA were invited to attend special clinics for interview and examination in order to verify their diagnoses and collect the data necessary for evaluating the ESSG criteria (5).

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“…Blood samples were collected at least 12 h after the last dosage of immunosuppressants to minimize the drug effects. The grade of sacroiliitis was identified according to the New York criteria [22] and the lumbar spine involvement was graded by the Bath Ankylosing Spondylitis Radiology Index (BASRI) [23] in AS patients.…”

Section: Patients and Controlsmentioning

confidence: 99%

Aberrant expression of microRNAs in T cells from patients with ankylosing spondylitis contributes to the immunopathogenesis

Lai

Chen

et al. 2013

Clinical and Experimental Immunology

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Summary Ankylosing spondylitis (AS) is a chronic inflammatory disorder characterized by dysregulated T cells. We hypothesized that the aberrant expression of microRNAs (miRNAs) in AS T cells involved in (TLR-4), a target of let-7i, in T cells from AS patients were decreased. In addition, the mRNA expression of interferon (IFN)-g was elevated in AS T cells. Lipopolysaccharide (LPS), a TLR-4 agonist, inhibited IFN-g secretion by anti-CD3+ anti-CD28 antibodiesstimulated normal T cells but not AS T cells. In the transfection studies, we found the increased expression of let-7i enhanced IFN-g production by anti-CD3 + anti-CD28 + lipopolysaccharide (LPS)-stimulated normal T cells. In contrast, the decreased expression of let-7i suppressed IFN-g production by anti-CD3 + anti-CD28 + LPS-stimulated AS T cells. In conclusion, we found that miR-16, miR-221 and let-7i were over-expressed in AS T cells, but only miR-221 and let-7i were associated with BASRI of lumbar spine. In the functional studies, the increased let-7i expression facilitated the T helper type 1 (IFN-g) immune response in T cells.

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New York clinical criteria for ankylosing spondylitis. A statistical evaluation.

Cited by 206 publications

References 10 publications

Synovial fluid exoglycosidases are predictors of rheumatoid arthritis and are effective in cartilage glycosaminoglycan depletion

Synovial fluid exoglycosidases are predictors of rheumatoid arthritis and are effective in cartilage glycosaminoglycan depletion

Evaluation of the european spondylarthropathy study group preliminary classification criteria in alaskan eskimo populations

Aberrant expression of microRNAs in T cells from patients with ankylosing spondylitis contributes to the immunopathogenesis

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