New York City, NY: Tin Pan Alley

Role of microRNAs in osteogenesis of stem cells

“…They even regulate osteoclast activity through the expression of receptor activator of nuclear factor-kB ligand, macrophage colony stimulating factor, and secretion of osteoprotegerin. [32][33][34] During embryonic development, bone formation is controlled by two processes: intramembranous vs endochondral ossification. Ossification is the development of the hard component of bone.…”

“…Osteopontin, also known as bone sialoprotein I (BSP-I or BNSP) is also expressed in this phase for the first time. 32 (2) Maturation phase and synthesis of ECM: preosteoblasts with minimal cell proliferation predominantly constitute this phase and mature into osteoblasts. Increased expression of alkaline phosphatase liver/ bone/kidney (ALPL), COL1A1, and integrin binding sialoprotein (IBSP) is seen during this phase.…”

“…Increased expression of alkaline phosphatase liver/ bone/kidney (ALPL), COL1A1, and integrin binding sialoprotein (IBSP) is seen during this phase. 32 (3) Mineralization phase: in this phase mature osteoblasts are predominant cells and there are no proliferative…”